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Peptide epitopes from herpes simplex virus glycoprotein confer immunity.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity have been identified.
"The molecular characterization of the epitope repertoire on herpes simplex virus (HSV) antigens would greatly expand our knowledge of HSV immunity and improve immune interventions against herpesvirus infections. HSV glycoprotein D (gD) is an immunodominant viral coat protein and is considered an excellent vaccine candidate antigen. By using the TEPITOPE prediction algorithm, we have identified and characterized a total of 12 regions within the HSV type 1 (HSV-1) gD bearing potential CD4+ T-cell epitopes, each 27 to 34 amino acids in length," scientists in the United States report.
"Immunogenicity studies of the corresponding medium-sized peptides confirmed all previously known gD epitopes and additionally revealed four new immunodominant regions (gD[subscript]49-82, gD[subscript]146-179, gD[subscript]228-257, and gD[subscript]332-358), each containing naturally processed epitopes," stated Lbachir BenMohamed and colleagues at the University of California-Irvine. "These epitopes elicited potent T-cell responses in mice of diverse major histocompatibility complex backgrounds. Each of the four new immunodominant peptide epitopes generated strong CD4+ ...
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Source: HighBeam Research, Peptide epitopes from herpes simplex virus glycoprotein confer...