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AIDS vaccine protects against infection in a macaque AIDS model.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- A single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector was protective in a macaque AIDS model.
According to a study from Japan, "We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques."
"Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections," wrote Akiko Takeda and collaborators at the University of Tokyo, National Institute of Infectious Diseases, and DNAVEC Research Inc. in Japan.
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...Fusing C3d to Env enhanced humoral responses in animals * The best results were achieved with Env-C3d DNA priming followed by boosting with purified gp120 This article was prepared by Vaccine Weekly editors from staff and other reports...
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- Newspaper article from: AIDS Vaccine Week June 15, 2009 700+ words
...peak postchallenge viremia for a heterologous challenge." "Vaccine studies were conducted in rhesus macaques using DNA priming followed by modified vaccinia Ankara boosting with HIV type 1 (HIV-1) immunogens that express virus-like particles displaying...
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...functions, and memory T cell development (15-21). However, these studies focus on a single antigenic encounter (priming followed by removal from the antigenic environment) and do not separate these initial events from the later (post-priming...
- New anthrax study findings reported from University of Maryland.
- News wire article from: Bioterrorism Week February 23, 2009 700+ words
...researchers concluded: "In nonhuman primates, the success of this anthrax vaccine strategy based on heterologous mucosal priming followed by a parenteral subunit vaccine booster paves the way for clinical trials." Galen and colleagues published their study...
Source: HighBeam Research, AIDS vaccine protects against infection in a macaque AIDS model.