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Pdef expression in breast cancer correlates with invasion and gene alteration.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Pdef expression in breast cancer correlates with invasion and gene alteration.
According to recent research from the United States, "Ets transcription factors control multiple biological processes, including cell proliferation, differentiation, apoptosis, angiogenesis, transformation, and invasion. Pdef is an Ets transcription factor originally identified in prostate tissue. We demonstrate that human Pdef is expressed at high levels primarily in tissues with high epithelial cell content, including prostate, colon, and breast."
"We also determined that Pdef protein is reduced in human invasive breast cancer and is absent in invasive breast cancer cell lines. We next assessed the functional consequences of these observations. Significantly, expression of Pdef in breast cancer cells leads to inhibition of invasion, migration, and growth," said R.J. Feldman and colleagues, Medical University of South Carolina, Hollings Cancer Center.
"Expression of Pdef also results in the down-regulation of urokinase-type plasminogen activator and activation of the promoter of ...
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Source: HighBeam Research, Pdef expression in breast cancer correlates with invasion and gene...