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Oxygen changes shift angiogenic factors to cause fetal growth restriction.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Oxygen changes shift angiogenic factors to cause fetal growth restriction.
"Placental growth factor (PlGF) and vascular endothelial growth factor (VEGF) are involved in placental angiogenesis through interactions with the VEGFR-1 and VEGFR-2 receptors. The placenta of pregnancies whose outcome is fetal growth restriction (FGR) are characterized by abnormal angiogenic development, classically associated with hypoxia. The present study evaluated the near-term expression of this growth factor family in an ovine model of placental insufficiency-FGR, in relationship to uteroplacental oxygenation," scientists in the United States reported.
"Compared to controls, FGR pregnancies demonstrated a 37 % increase in uterine blood flow (FGR vs. control, 610.86[+ or -]48.48 vs. 443.17[+ or -]37.39 ml min[superscript]-1 (kg fetus)[superscript]-1; p
"Maternal caruncle PlGF mRNA was increased in FGR (p
"The data establish that uterine blood flow is not reduced in relationship to metabolic demands in this FGR model and that the transplacental P-O[subscript]2 gradient is increased, maintaining umbilical oxygen uptake per unit of tissue. Furthermore, these data suggest that an increased transplacental gradient of oxygen generates changes in angiogenic growth factors, which may underline the pathophysiology of the post-placental hypoxic FGR," researchers concluded.
Regnault and colleagues published their study in Journal of Physiology - London (The relationship between transplacental O[subscript]2 diffusion and placental ...
- Ability to detect intrauterine fetal growth restriction ... 'must try...
- Magazine article from: Royal College of Midwives-Evidence-Based Midwifery Dornan, James C. September 1, 2008 700+ words
...clinically detect intrauterine fetal growth restriction (IUGR), and thus potentially...often associated with abnormal fetal growth patterns. Should we continue...majority are associated with growth restriction. The majority of these babies...
- 'Thrifty Phenotype' Hypothesis Gains Ground. (Implications Of Fetal Growth...
- Magazine article from: OB GYN News Jancin, Bruce October 15, 2001 700+ words
...the 'thrifty phenotype hypothesis, holds that fetal growth restriction is an important cause of some of the most common...convincingly demonstrated a powerful link between fetal growth restriction as reflected in low birth weight and increased...
- Mechanisms of hypoxia-induced fetal growth restriction studied.
- Newspaper article from: Biotech Week December 8, 2004 700+ words
...Molecular mechanisms underlying fetal growth restriction due to placental insufficiency...underlying hypoxia-related fetal growth restriction. "Furthermore, induction...the major subject areas of Fetal Growth, Hypoxia, Obstetrics...
- Intrauterine fetal growth restriction alters factors affecting salt metabolism.
- Newspaper article from: OBGYN & Reproduction Week March 22, 2004 700+ words
...com & NewsRx.net) -- Intrauterine fetal growth restriction alters factors affecting salt metabolism. According...are unclear. We tested whether intrauterine fetal growth restriction results in salt-sensitive offspring that exhibit...
- Maternal Thrombotic Mutations Linked To Infants' Low Birthweight.(women with...
- Magazine article from: Women's Health Weekly April 26, 2001 700+ words
...of having children with fetal growth restriction (FGR), according to...and the occurrence of fetal growth restriction," Haematologica, April...delivering children with fetal growth restriction (FGR) * Prothrombin...
- Study ID's fetal growth restriction cause.
- News wire article from: UPI Energy Resources September 17, 2009 700+ words
...kinase Erk3 in mice leads to fetal growth restriction and early neonatal lethality...mortality. Intrauterine growth restriction, the scientists said...Infants with (intrauterine growth restriction) have a significant risk...
- Maternal anthropometric characteristics impact fetal growth restriction.
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...appear to be risk factors for term or near-term fetal growth restriction (FGR) in uncomplicated pregnancies. Pediatricians...Perinatology (Risk factors for term or near-term fetal growth restriction in the absence of maternal complications. Am...
- Strong early data for Ark fetal growth restriction drug.(Ark Therapeutics...
- Newspaper article from: Pharma Marketletter May 26, 2008 700+ words
UK-based drug developer Ark Therapeutics says that results from the first trial in a preclinical model of blood flow to the placenta have shown that a single treatment with EG013, given directly into the mother's uterine artery, increased blood flow to the placenta by 25%, an improvement that is
