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D2S2944 allele linked to depression and substance abuse in women.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- A D2S2944 allele is associated with an increased risk of depression and substance abuse in women.
"Major depressive disorder (MDD) and substance use disorders (SUD) are complex behavioral disorders with 40%5-50% heritability," scientists in the United States noted. "Recently, Zubenko and colleagues reported that the 124 bp allele of D2S2944, a tetranucleotide repeat marker on 2q35, is strongly associated with recurrent, early onset MDD (RE-MDD) and alcohol use disorders in women."
"To test this hypothesis," R. Philibert and colleagues at the University of Iowa "examined the association of the 124 bp allele in a subset of 171 adoptees from the Iowa Adoption Studies, a population with high rates of MDD and SUD."
In the study cohort, "the 124 bp allele significantly associated with RE-MDD in women," they found. "There was slight evidence of an increased of SUD in women with the 124 bp allele with the rate of cannabis use disorders reaching statistical significance (p
"Given the history of prior studies implicating 2q35 as a locus encoding vulnerability to co-morbid alcoholism and ...
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...association of the frequency of the 252 bp allele in a certain portion of the PTHrP gene...association between the frequency of the 252 bp allele in the VNTR region of the PTHrP gene...subjects had at least one copy of the 252 bp allele in the VNTR region of their PTHrP gene...
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...presence of at least one 252 base pair (bp) allele was associated with increased skeletal...and the presence of at least one 378 bp allele was associated with decreased densitometric...was strengthened by pairing of the 252 bp allele with a 460 bp allele. In contrast...
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...a statistical difference in the 232-bp allele distribution of the BDNF gene (GT...In early onset patients, the 234-bp allele had a risk role. For the chlorpromazine...induced extrapyramidal syndrome, the 230-bp allele and the 234-bp allele acted in opposite...
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...strengthened by the pairing of the 2 52 bp allele with a 460 bp allele in comparison with those without any 252 bp allele. Electrophoretic mobility shift...This article was prepared by Women's Health Weekly editors from...
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...neonates were homozygous for the 192-bp allele (wild-type), 48% were heterozygous...counts were observed between the 192-bp allele heterozygous and homozygous groups...counts (P = 0.36) than in the 192-bp allele homozygous group. Analyses of T lymphocyte...
- Researchers at Virginia Commonwealth University publish new data on thrombosis.
- Newspaper article from: Blood Weekly March 12, 2009 700+ words
...VAT predictors included the NOS3 420 bp allele (P=0.03) and the presence of a...P=0.02); however, the NOS3 420 bp allele failed to improve the model. These data...researchers concluded: "The NOS3 420 bp allele may have an association with thrombosis...
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...between SC and EEA, with more EEA subjects carrying the 164 bp allele (P=0.007)," wrote B. Wolfarth and colleagues, Technical...In summary, we found suggestive evidence that the 164 bp allele of the (CA)(n) repeat in intron 13 is associated with...
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...varying degrees of height reduction or promotion. The 192-bp allele of Xgwm 261 is indicative of the more commercially favorable...dwarfing genes. Thus, we hypothesized that the Xgwm 261 192-bp allele diagnostic of Rht8 could be identified in advanced breeding...
Source: HighBeam Research, D2S2944 allele linked to depression and substance abuse in women.