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2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Platelet populations become different after abdominal uterine removal.
"This study was designed to clarify the quantitative relationship between platelet aggregation and the secretion of adenosine triphosphate (ATP) after surgery. Peripheral blood was collected from 41 patients who underwent abdominal total hysterectomy. Platelet count, volume, aggregation and, the amount of secreted ATP were determined using live platelets before, one day after and two weeks after surgery," researchers in Japan reported.
"Platelet aggregation and ATP secretion were investigated using a lumi-aggregometer. The aggregating reagents used were 5 micro M of adenosine diphosphate (ADP) (final concentration) and 5 mcg/ml of collagen. Structural alterations of platelets at these time points were also investigated by electron microscopy," said M. Hayashi and colleagues, Dokkyo University, Koshigaya Hospital.
"Platelet aggregation induced by collagen was significantly lower (p
"In conclusion, after consumption of circulating platelets at the site of operation, in addition to being lost by bleeding, the remaining platelets in circulation consist of platelet subpopulations different from those present before surgery, exhibiting low values of correlation coefficients between platelet aggregation and secretion of ATP and low concentrations of granules," researchers said.
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