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Uterine fibroids tend to display antiangiogenic gene expression profiles.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- According to recent research from Australia, "the etiology of uterine fibroids remains unknown, despite causing significant gynecological morbidity. Fibroids have a reduced microvascular density when compared with adjacent myometrial tissue. The aim of this study was to identify genes with differential expression between fibroid and adjacent normal myometrium, particularly genes with a role in angiogenesis."
"Total RNA was extracted from fibroid/myometrium pairs from 12 hysterectomy specimens and used to perform 24 cDNA microarrays. There were 10 500 genes screened on each microarray for differential expression. Analysis of expression data was carried out using multiple t-tests, as well as a novel class prediction algorithm (GeneRaVE(TM)). The differential gene expression of selected genes was confirmed by quantitative 'real time' RT-PCR," G. Weston and colleagues, Monash University, Center for Women's Health Research said.
"Selected genes with a role in angiogenesis were further analyzed for expression in isolated cell populations of endothelial cells (fibroid and myometrium) and smooth muscle cells (fibroid and myometrium), to see if their expression was confined to particular cell types. Twenty-five genes with differential gene expression between fibroid and myometrium were identified."
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Source: HighBeam Research, Uterine fibroids tend to display antiangiogenic gene expression...