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Fc receptor mediates antibody regulation of T-cell immunity.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Antibody regulation of T-cell immunity against intracellular pathogens is Fc receptor-mediated.
"Immunity to intracellular microbial pathogens, including Chlamydia species, is controlled primarily by cell-mediated effector mechanisms, yet, the absence of antibodies results in inefficient microbial clearance. We investigated the hypothesis that certain Fc receptor functions promote the rapid induction of elevated T helper type 1 (Th1) response, which effectively clears chlamydiae," investigators in the United States report.
"FcR[superscript]-/- mice exhibited a delayed and reduced frequency of Chlamydia-specific Th1 cells, compared to FcR[superscript]+/+ mice," stated Terri Moore and colleagues at the Centers for Disease Control and Prevention. "In vitro, antichlamydial antibodies increased the rate of Th1 activation by FcR[superscript]+/+ but not FcR[superscript]+/+ antigen-presenting cells. FcR[superscript]-/- dendritic cells and the T cell-associated IgG2A and IgA mediate enhanced Th1 activation by antibodies. Immunization with chlamydia-antibody complexes induced elevated and protective Th1 response."
"These results provide a mechanistic ...
- InKine Pharmaceutical Announces Issuance of Fc Receptor Gene Therapy Patent.
- Press release article from: Business Wire October 27, 1998 700+ words
...Alan D. Schreiber's patent covering Fc receptor and Syk kinase gene therapy has issued...additional patent issued covering the use of Fc receptor gene therapy in the lung. These inventions...introduction of a gene for an appropriate Fc receptor. The current patent results from Dr...
- Novel polymorphism in cytoplasmic region of IgA Fc receptor gene found.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...polymorphism in the cytoplasmic region of the IgA Fc receptor gene has been found. "The Fc receptor for immunoglobulin A (IgA), FcalphaRI...polymorphism in exon 5 of the immunoglobulin A Fc receptor (FCAR) gene leading to a Ser-->...
- MHC class I-like Fc receptor promotes humoral autoimmune disease.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...promoted by FcRn in mice. "The MHC class I family-like Fc receptor, FcRn, is normally responsible for extending the life span...Journal of Clinical Investigation (The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest...
- SuppreMol gets $25m for recombinant Fc receptor.
- Newspaper article from: BioWorld International Sheridan, Cormac July 16, 2008 700+ words
...normal binding that occurs between an immune complex and an Fc receptor present on the surface of a macrophage. "Immune complexs...were first to solve the three-dimensional structure of an Fc receptor. The financing round was led by Munich-based MIG AG, Stuttgart...
- Fc receptor aggregation has inhibitory effect on pre-B cells.
- Newspaper article from: Biotech Week June 30, 2004 700+ words
...FcR aggregation inhibits pre-B cell migration and proliferation. "Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors," immunologists in the...
- Prima obtains Fc receptor patent.
- Newspaper article from: BIOTECH Patent News July 1, 2003 700+ words
...Arthron Ltd has succeeded in securing an Australian patent protecting the three dimensional structure of its drug target, the Fc receptor (FcR), and use of this structure to design drugs targeted at diseases, such as rheumatoid arthritis, that involve the...
- (AEPRR) Prima Biomed deal with Xencor for Fc receptor technology.
- News wire article from: Asia Africa Intelligence Wire September 8, 2005 700+ words
...ASX:PRR) has a licence and option agreement with US biotech Xencor Inc whereby Xencor has a non-exclusive right to use Fc receptor technology for up to two years in internal research. It also has an option to receive a non-exclusive licence to use the...
- Inkine Pharmaceutical announces issuance of patents for Fc receptor technology...
- Newspaper article from: BIOTECH Patent News June 1, 2000 700+ words
...defense against infection, the fourth leading cause of death in the United States." CBP-1011 is a compound derived from the Fc receptor technology which is currently being used in a Phase III clinical trial for ITP, and Phase II trials for the treatment of...
- InKine Pharmaceutical Announces Issuance of Patents for Fc Receptor Technology...
- Press release article from: PR Newswire June 14, 2000 700+ words
...defense against infection, the fourth leading cause of death in the United States." CBP-1011 is a compound derived from the Fc receptor technology which is currently being used in a Phase III clinical trial for ITP, and Phase II trials for the treatment of...
- PRIMABioMed obtains patent on three dimensional (3D) structure of the Fc...
- Newspaper article from: BIOTECH Patent News August 1, 2003 700+ words
...States Patent and Trademark Office that it will allow an application relating to the three dimensional (3D) structure of the Fc receptor (FcR), the target of drugs being developed by its subsidiary Arthron Ltd. for the treatment of autoimmune inflammatory...
Source: HighBeam Research, Fc receptor mediates antibody regulation of T-cell immunity.