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Genetic alterations at chromosome 6 associated with cervical cancer progression.

Women's Health Weekly

| October 02, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Genetic alterations at chromosome 6 are associated with cervical cancer progression.

"Loss of heterozygosity (LOH) analysis on chromosome 6 was performed to define the genetic changes that occur in the development of squamous cell cervical cancer (SCC)," scientists writing in the journal Molecular Biology report.

"Detailed analysis with 28 microsatellite markers revealed several loci with high frequency of deletions at the short (6p25, 6p22, 6p21.3) and long (6q14, 6q16-q21, 6q23-q24, 6q25, 6q27) arms of chromosome 6," wrote N.N. Mazurenko and colleagues, Russian Academy of Medical Science, Blokhin Cancer Research Center.

"Examination of microdissected 37 SCC and 22 cervical intraepithelial neoplasias (CIN) revealed allelic deletions in the HLA class I-III region (6p22-p21.3) and at subtelomeric locus 6p25-ter in more than 40% of CIN," the researchers wrote.

"By a combination of LOH and microdissection of multiple samples from the same tumor sections, we studied the intratumoral genetic heterogeneity of SCC, and identified clonal and subclonal allelic deletions," the ...

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Source: HighBeam Research, Genetic alterations at chromosome 6 associated with cervical cancer...

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