AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
The hepatocyte growth factor antagonist NK4 reduces breast malignancies.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- "Hepatocyte growth factor/scatter factor (HGF/SF) is a cytokine primarily produced by stromal fibroblasts and is a known angiogenic and invasion-inducing factor. It is increased in patients with breast cancer. This study examined the effect of NK4, a newly described HGF/SF antagonist, on HGF/SF-promoted growth of a human breast cancer," researchers in Wales report.
"Both in vitro (invasion and migration assays) and in vivo (murine tumor model) methods were used to ascertain the effect of NK4 on HGF/SF from two sources: human fibroblast-derived HGF/SF and recombinant HGF/SF. In the in vitro invasion assay and migration assay, both HGF/SF and human fibroblasts, which secrete bioactive HGF/SF, increased the invasiveness and migration of the breast cancer cells (MDA MB 231)," commented T.A. Martin and colleagues, University of Wales College of Medicine, Metastasis Research Group.
"NK4 significantly reduced this invasiveness and motility. In the animal model, tumor volume and weight was significantly reduced with addition of NK4. It also suppressed HGF/SF-induced growth and markedly retarded tumor growth induced by fibroblasts (MRC5) secreting bioactive HGF/SF."
"Tumor angiogenesis was assessed by ...
- SBB MUTUAL DECLARES 10 SEN INCOME DISTRIBUTION FOR HGF SEQUEL FUND & SF.
- News wire article from: Asia Africa Intelligence Wire July 2, 2004 700+ words
...sen per unit for all unitholders of SBB HGF Sequel Fund (Sequel) and SBB Savings Fund (SF) respectively today. The SBB HGF Fund was introduced in March 2001 as...investors who purchased units of Sequel and SF no later than 5.00pm or before June...
- This Essential c-MET/HGF Inhibitors Target and Company Pipelines Report...
- Press release article from: M2 Presswire September 29, 2008 700+ words
...RTK) and its ligand hepatocyte growth factor (HGF) or scatter factor (SF) for treatment of solid tumors. Current approaches...hepatocyte growth factor (HGF) or scatter factor (SF). Binding of HGF/SF to c-MET activates downstream signalling pathways...
- AVEO Presents Novel HGF Model and Promising Preclinical Activity to Support...
- Press release article from: Business Wire April 19, 2009 700+ words
...novel human hepatocyte growth factor (HGF) knock-in model and announced data...hepatocyte growth factor/scatter factor (HGF/SF). Additionally, data assessing Fibroblast...hepatocyte growth factor/scatter factor (HGF/SF), which has demonstrated excellent...
- AVEO Pharmaceuticals Initiates First Clinical Trial of Novel HGF Antagonist in...
- Press release article from: Business Wire September 23, 2008 700+ words
...and lung, suggesting that targeting HGF may provide a novel way of treating...hepatocyte growth factor/scatter factor (HGF/SF), which has demonstrated excellent...characteristics of tumors in which the HGF/c-Met pathway plays a critical...
- XOMA and AVEO Announce Agreement to Apply Human Engineering(TM) Technology to...
- Press release article from: PR Newswire April 27, 2006 700+ words
...humanize AV-299, AVEO's novel anti-HGF monoclonal antibody. For work conducted...hepatocyte growth factor/scatter factor (HGF/SF) which has demonstrated excellent...affinity antibody whose binding to HGF potently neutralizes the biological...
- AVEO Enters into Worldwide License and Development Agreement with Schering-...
- Press release article from: PR Newswire April 4, 2007 700+ words
...hepatocyte growth factor/scatter factor (HGF/SF) which has demonstrated excellent...hepatocyte growth factor/scatter factor (HGF/SF), which has demonstrated excellent...preclinical models of human cancer. The HGF/c-Met pathway is frequently deregulated...
- AVEO and XOMA Enter Into Supply Agreement for AVEO's Novel Anti-HGF Antibody.
- Press release article from: PR Newswire September 28, 2006 700+ words
...supply AV-299, AVEO's novel anti-HGF antibody, in support of early clinical...hepatocyte growth factor/scatter factor (HGF/SF), which has demonstrated excellent...preclinical models of human cancer. The HGF/c-Met pathway is frequently deregulated...
- Aveo presents novel HGF Model and promising pre-clinical activity to support...
- News wire article from: Chemical Business Newsbase April 19, 2009 700+ words
...novel human hepatocyte growth factor (HGF) knock-in model and announced data...hepatocyte growth factor/scatter factor (HGF/SF). Additionally, data assessing Fibroblast...stromal-endothelial interactions of HGF/c-Met axis in pre-clinical efficacy...
- Aveo and Xoma enter into supply agreement for AVeO's novel anti-HGF antibody.
- News wire article from: Chemical Business Newsbase September 28, 2006 700+ words
...manufacture and supply AV-299, Aveo's novel anti-HGF antibody, in support of early clinical trials. The companies...antagonist of hepatocyte growth factor/scatter factor (HGF/SF), which has demonstrated excellent efficacy in pre-clinical...
- Pseudopodial motility shown to be regulated by HGF-R/Met tyrosine kinase.
- Newspaper article from: Proteomics Weekly February 24, 2003 700+ words
...for the hepatocyte growth factor receptor (HGF-R), otherwise known as c-met proto-oncogene. Cell surface expression of HGF-R was similar in the three cell lines, indicating that HGF-R is constitutively phosphorylated in MSV...
Source: HighBeam Research, The hepatocyte growth factor antagonist NK4 reduces breast...