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New alternatives in breast cancer treatment reported.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Researchers from M.D. Anderson Cancer Center in Houston, Texas, report on new alternatives in treating postmenopausal women with hormone-responsive breast cancer in The Oncologist.
New endocrine therapies used to treat breast cancer have been approved in the United States. Aromatase inhibitors (AIs) and fulvestrant (Faslodex) are the newer alternatives discussed in a new paper authored by Dr. Aman U. Buzdar (Oncologist 2003;8(4)).
Hormone-sensitive breast cancer can be effectively treated with drugs that reduce the occurrence of tumor cells. For more than 2 decades the anti-estrogen drug tamoxifen has been the hormonal treatment of choice for first-line treatment in postmenopausal patients with hormone-sensitive metastatic and early breast cancer. However, there are concerns with its safety and tolerability.
The newer AIs (eg, anastrozole and letrozole) are as effective as or more effective than those previously used, more effective than progestins, such as megestrol acetate, and also tamoxifen when used as a second- and first-line treatment for postmenopausal patients with metastatic breast cancer.
Anastrozole is the only AI with published clinical trial data and FDA approval for adjuvant therapy in postmenopausal women with early breast cancer. "Updated follow-up has shown evidence of a superior therapeutic index for anastrozole compared ...
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Source: HighBeam Research, New alternatives in breast cancer treatment reported.