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Estrogen may actually exacerbate neural injury in older adult females.

Women's Health Weekly

| October 02, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Estrogen may actually exacerbate neural injury in older adult females.

"Estrogen attenuates neural damage resulting from a variety of experimental injury models in adult female rats. To determine whether estrogens neuroprotective actions are age-specific, the present study compared the effects of estrogen on young adult and reproductive senescent animals subject to excitotoxic injury to the forebrain. NMDA was injected bilaterally into the olfactory bulbs of estrogen and placebo-replaced young adult and reproductive senescent animals," investigators in the United States reported.

"Lysates of the olfactory bulb and its basal forebrain afferent, the horizontal limb of the diagonal band of Broca (hlDBB), harvested 24 hours later were analyzed for expression of IL-1beta, IL-10, and nerve growth factor (NGF). NMDA injections resulted in local activation of microglia and an increase in interleukin (IL)-1beta. Estrogen replacement decreased IL-1beta expression in young adult females, but paradoxically enhanced its expression in reproductive senescent females," said V.L. Nordell and colleagues, Texas A&M University Systems, Department of Human Anatomy and Medical Neurobiology.

"Furthermore, bulb injury increased IL-1beta production in the hlDBB of reproductive senescent animals although estrogen replacement was able to suppress lesion-induced expression of this ...

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Source: HighBeam Research, Estrogen may actually exacerbate neural injury in older adult females.