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Reproductive hormones may affect the efficacy of serotonergic antidepressants.
2003 OCT 2 - (NewsRx.com & NewsRx.net) -- Reproductive hormones may affect the efficacy of serotonergic antidepressants.
"The objective of this report is to compare antidepressant response rates and tolerability in younger and older women. One hundred fifteen female outpatients who met DSM-IV criteria for major depressive disorder were evaluated before and after 8 weeks of treatment with a selective serotonin reuptake inhibitor, nefazodone, or venlafaxine. The sample was divided into younger and older groups based on age to approximate premenopausal and postmenopausal status," researchers in Canada reported.
"Eighty-six age-matched male outpatients fanned the comparison group. Younger women compared with older women had significantly lower Hamilton Rating Scale for Depression scores after 8 weeks of antidepressant treatment and achieved significant higher rates of remission," S. Grigoriadis and colleagues, University of Toronto, University Health Network stated.
"There were no differences in overall drug tolerability. This pattern was not replicated in the male patients. Younger women with ...
- Reproductive hormones may affect the efficacy of serotonergic antidepressants.
- Newspaper article from: Drug Week October 3, 2003 700+ words
...efficacy of serotonergic antidepressants. "The objective...responsive to serotonergic antidepressants. This may...Journal of Clinical Psychopharmacology (A comparison...Journal of Clinical Psychopharmacology is: Lippincott...
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The American Society of Clinical Psychopharmacology (ASCP) has adopted The Journal of Clinical Psychiatry as its official journal. Published by Memphis-based Physician's Postgraduate Press, the 67-year-old journal boasts a circulation of 35,000.
