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2003 OCT 1 - (NewsRx.com & NewsRx.net) -- An update on epitope identification, and vaccine design and delivery has been published in a recent issue of Current Opinion in Immunology.
"The basic premise of the epitope-based approach to vaccine development is that, in certain cases, the responses induced by the natural immunogen are not optimal, and can be improved upon by isolation or optimization of specific components of the response," scientists in the United States report.
"For example, immunodominance is a key factor limiting the type and breadth of adaptive immunity," stated Alessandro Sette and John Fikes at the La Jolla Institute for Allergy and Immunology. "Recent advances in understanding the mechanisms of immunodominance thus represent an opportunity to further develop the ...