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Two parasites' genes sequenced.
2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Two groups have reported on the sequencing and analysis of most of the genes found in two of the parasites that cause schistosomiasis, a significant cause of morbidity and mortality in the developing world.
The initial analysis of the protein-coding portion of these genomes has shed light on their evolution and physiology and promises to be an important public resource for the development of new vaccines and drugs to prevent and treat the disease.
Ze-Guang Han and colleagues at the Chinese National Human Genome Center in Shanghai led a team that sequenced and annotated more than 13,000 genes that are known to be expressed in Schistosoma japonicum, the parasite that causes schistosomiasis in China and other Asian countries.
Their findings were reported in the October 2003 issue of Nature Genetics. S. japonicum has a total of approximately 15,000 genes. Sergio Verjovski-Almeida and colleagues at the University of Sao Paulo sequenced and analyzed 92% of the estimated 14,000 genes of Schistosoma mansoni, which is endemic to Africa, the Caribbean and South America. Of the expressed sequences identified in S. japonicum, 35% shared no similarity with known genes, and 75% had not been reported previously in schistosomes. Of those genes that ...
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Source: HighBeam Research, Two parasites' genes sequenced.