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Haemophilus influenzae type b disease increasing in vaccinated children.

Vaccine Weekly

| October 01, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Haemophilus influenzae type b disease is increasing among vaccinated children in the U.K.

"In October 1992, Haemophilus influenzae type b (Hib) conjugate vaccine was introduced to infants in the United Kingdom with a 'catch-up' program for those aged

"Between October 1993 and December 2001, a total of 443 cases of Hib infection occurred in children eligible for vaccination; 363 (82%) were fully vaccinated," stated Mary E. Ramsay at the Communicable Disease Surveillance Centre in London and collaborators in, UK. "Vaccine effectiveness was estimated to be 56.7% (95% confidence interval, 42.5-67.4). Effectiveness was lower in children vaccinated during infancy, compared with those who were vaccinated during the catch-up campaign (p=0.0033), declined with time since vaccination (p=0.0008), and was lower in children born during 2000-2002, compared with other children scheduled for infant vaccination (p=0.0041)."

"Use of a catch-up vaccination program enhanced the control of Hib infection in England and Wales," reported Ramsay and her colleagues. "Since 1999, however, low effectiveness in infants, declining effectiveness with age, and the use of lower-efficacy vaccines have contributed to increased ...

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