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HPV-16-transformed cells expressing herpes thymidine kinase induce immunity.
2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-2 (IL-2) had antitumor effects.
According to recent research published in the International Journal of Oncology, "From mouse (C57BL/6) HPV-16 transformed cells denoted MK16/1/IIIABC (MK16) a cellular thymidine kinase deficient (cTK-) cell line was isolated. These cTK- cells were transduced by bicistronic recombinant adeno-associated viruses (rAAV) carrying the herpes simplex virus thymidine kinase gene and the gene for either the mouse GM-CSF or mouse IL-2."
"Transduced cells were highly sensitive to minute amounts of ganciclovir (GCV) and synthesized moderate amounts of the respective cytokines," reported P. Jinoch and colleagues at the Institute of Hematology and Blood Transfusion in the Czech Republic. "A number of cell clones were tested for the cytokine production. The two best producer cell lines, the GM-CSF-producing cells denoted B9 and the IL-2-producing cells denoted 181, were selected for further ...
- Bone cancer cells respond to HSV thymidine kinase-ganciclovir gene therapy.
- Newspaper article from: Drug Week June 25, 2004 700+ words
...simplex virus type 1 thymidine kinase (HSV-TK...their study in International Journal of Molecular Medicine...simplex virus thymidine kinase/ganciclovir...information for the International Journal of Molecular Medicine...
- HSV type 1 thymidine kinase/ganciclovir gene therapy targets lung cancer.
- Newspaper article from: Biotech Week May 26, 2004 700+ words
...simplex virus thymidine kinase/ganciclovir...their study in International Journal of Oncology...simplex type 1 thymidine kinase-ganciclovir...information for the International Journal of Oncology is...
- Mutant herpes simplex virus type 1 thymidine kinase a gene expression marker.
- Newspaper article from: Gene Therapy Weekly February 20, 2003 700+ words
...mutated herpes simplex virus type thymidine kinase enzyme may be better than its wild...delivery. Herpes simplex virus 1 thymidine kinase (HSV1-tk) is currently under intensive...mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene. Gene...
- Peptide fusion improves the efficacy of thymidine kinase suicide gene therapy.
- Newspaper article from: Cancer Weekly April 1, 2003 700+ words
...Peptide fusion improves the efficacy of thymidine kinase suicide gene therapy. According to...simplex virus type-1 (HSV-1) thymidine kinase (TK) is a widely exploited approach...Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide...
- Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells.
- Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells. "Selective...retrovirus-mediated gene transfer of herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblastoma cell line (neuro...
- HIV-1 that expresses HSV-1 thymidine kinase: implications for therapeutics and...
- Newspaper article from: AIDS Weekly Smith, S.M. Jeang, K.-T. March 27, 1995 700+ words
...Previously, it was shown that the production of HSV-1 thymidine kinase (TK) confers ganciclovir sensitivity to cells. To exploit...backbone with the first 80 bases of nef removed. In a thymidine kinase assay using LTK(-) cells, pNLTK produced 3.6 fold...
- M-CSF, IL-2 coexpression can augment the effect of HSVtk suicide gene...
- Magazine article from: Women's Health Weekly January 23, 2003 700+ words
...2 can enhance the effect of herpes simplex virus thymidine kinase gene suicide gene therapy. "Gene therapy for cancer using suicide genes such as the herpes simplex virus thymidine kinase gene (HSVtk) has been explored extensively in preclinical...
- Mouse lymphoma thymidine kinase gene mutation assay protocol discussed.
- Newspaper article from: Medical Letter on the CDC & FDA March 9, 2003 700+ words
...selection." Moore and her collaborators published their study in Environmental and Molecular Mutagenesis (Mouse lymphoma thymidine kinase gene mutation assay: Follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April...
- Cancer treatment uses 'suicide' gene. (thymidine kinase gene developed as...
- Magazine article from: Science News Travis, John August 3, 1991 700+ words
...Center expect final approval for this anticancer trial within eight months. Freeman's group plans to incorporate the thymidine kinase (tk) gene, isolated from the herpes simplex virus, into cultured human tumor cells. The enzyme this gene codes for...
- Withdrawal assessment report for Cerepro (adenovirus-mediated Herpes Simplex...
- News wire article from: Chemical Business Newsbase April 14, 2009 700+ words
...Medicines Agency (EMEA) published a withdrawal assessment report for Cerepro (adenovirus-mediated Herpes Simplex Virus-thymidine kinase gene). The applicant Ark Therapeutics Ltd submitted on 4 Oct 2005 an application for Marketing Authorisation to the European...
Source: HighBeam Research, HPV-16-transformed cells expressing herpes thymidine kinase induce...