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All-trans-retinoic acid improves effect of tumor vaccination.
2003 OCT 1 - (NewsRx.com & NewsRx.net) -- All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.
"Tumor-induced immunosuppression is one of the crucial mechanisms of tumor evasion of immune surveillance. It contributes greatly to the failure of cancer vaccines. Immature myeloid cells (ImCs) play an important role in tumor-induced immunosuppression," scientists in the United States report.
"These cells accumulate in large numbers in tumor-bearing hosts and directly inhibit T-cell functions via various mechanisms," stated Sergei Kusmartsev and colleagues at the University of South Florida. "In this study, we tried to eliminate ImCs in an attempt to improve antitumor response. In vivo administration of all-trans-retinoic acid (ATRA) dramatically reduced the presence of ImCs in all tested tumor models. This effect was not because of a direct antitumor effect of ATRA or decreased production of growth factors by tumor cells."
"Experiments with adoptive transfer demonstrated that ATRA differentiated ImC in vivo into mature dendritic cells, macrophages, and granulocytes," reported the investigators. "Decreased presence of ImC in tumor-bearing mice noticeably improved ...
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Source: HighBeam Research, All-trans-retinoic acid improves effect of tumor vaccination.