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2003 OCT 1 - (NewsRx.com & NewsRx.net) -- Progress in the field of cancer vaccines has been reported in a recent issue of the journal Cellular and Molecular Life Sciences.
According to a study from France, "The observation that in some cases tumors undergo spontaneous regression concomitantly with autoimmune manifestations has been interpreted as an indication of the involvement of the immune system in tumor rejection. This raised the conceptual possibility that the immune system could be used against the tumor. However, since tumor cells are poorly immunogenic by themselves, early attempts to develop immune-based approaches for cancer therapy saw the use of tumor cells transduced with genes coding for cytokines or costimulatory molecules to enhance in vivo immunity."
"The identification of cytotoxic T lymphocyte (CTL)-defined tumor-associated antigens has allowed the development of new strategies for cancer immunotherapy," said Toufic Renno and collaborators at Schering Plough Corporation. "Novel adjuvants ...