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2003 SEP 17 - (NewsRx.com & NewsRx.net) -- A therapeutic vaccine controlled stromal tumor-induced immunosuppression in human uterine cervix cancer.
"Cancer cells may escape immune surveillance by secreting in their microenvironment soluble factors that may locally paralyze the stromal effector immune cells. In the human uterine cervix cancer, HPV-16 E7 protein, released in the stroma, should contribute to cancer cells immune escape since this protein inhibits the cellular immune response to recall antigens or alloantigens and strongly enhances the release of immunosuppressive cytokines by APCs," investigators in France report.
"This prompted us to prepare a therapeutic vaccine triggering anti-E7 neutralizing antibodies to antagonize the E7-induced stromal immunosuppressive effects and allow cellular immune reaction towards cancer cells including specific CTLs, induced by conventional vaccine, to be effective," stated Helene Lebuanec and colleagues at the Universite Pierre et Marie Curie in Paris. ...