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Mutational differences occur in the IgG V-H gene in B cells due to ageing.

Vaccine Weekly

| September 10, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 SEP 10 - (NewsRx.com & NewsRx.net) -- Mutational differences occur in the IgG V-H gene in B cells due to ageing.

According to recent research published in the journal Clinical and Experimental Immunology, "To investigate age related alterations in human humoral immunity, we analyzed Ig heavy chain variable region genes expressed by peripheral B cells from young and aged individuals. Three hundred and twenty-seven cDNA sequences, 163 micro and 164 gamma transcripts with V-H 5 family genes, were analyzed for somatic hypermutation and V-H DJ(H) recombinational features. Unmutated and mutated micro transcripts were interpreted as being from naive and memory IgM B cells, respectively.

"In young and aged individuals, the percentages of naive IgM among total micro transcripts were 39% and 42%, respectively. D and J(H) segment usage in naive IgM from aged individuals was similar to that from young individuals. The mutational frequencies of memory IgM were similar in young and aged individuals. Gamma transcripts, which are regarded as being from memory IgG B cells, showed a significantly higher mutational frequency (7.6%) in aged than in young individuals (5.8%) (p

The researchers ...

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Source: HighBeam Research, Mutational differences occur in the IgG V-H gene in B cells due to...