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Two-dose hepatitis B vaccination schedule immunogenic in adults.

Vaccine Weekly

| September 10, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 SEP 10 - (NewsRx.com & NewsRx.net) -- A two-dose schedule of hepatitis B immunization was immunogenic in adults.

According to a study from Pakistan and Cuba, "Healthy subjects (15-50 years old) were randomized to receive, intramuscularly, 10 or 20 micrograms of a yeast-derived recombinant hepatitis B vaccine (Heberbiovac HB) on a two-dose (0-1) schedule."

"Anti-hepatitis B surface antigen antibodies (HBsAb) were determined at two, three and six months," reported Najib ul-Haq at Khyber Medical College in Pakistan and collaborators in Pakistan and Cuba. "Twenty micrograms immunization yielded 96.3% seroprotection (HBsAb >10 IU/L) at t=3, which persisted to 97.2% at t=6. The 10 microgram group resulted in 87.4% seroprotection at t=3 and 81% at t=6, but reached >95% among subjects

"It is concluded that the vaccine used is highly immunogenic and the two-dose 20 microgram immunization can be used in all age groups and 10 microgram in subjects up ...

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Source: HighBeam Research, Two-dose hepatitis B vaccination schedule immunogenic in adults.

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