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Vaccine for tumors secreting parathyroid hormone-related protein developed.
2003 SEP 10 - (NewsRx.com & NewsRx.net) -- A vaccine that shows promise against tumors, such as prostate cancer tumors, that secrete parathyroid hormone-related protein has been developed.
"Parathyroid hormone-related protein (PTH-rP), a secreted protein produced by prostate carcinoma and other epithelial cancers, is considered a key agent for the development of bone metastases. We investigated the construct GC90/IRIV, composed of immunopotentiating reconstituted influenza virosomes (IRIV) containing PTH-rP gene plasmids (GC90), as a potential tool for human anticancer immunotherapy into humanized mice transgenic for HLA-A(*) 02.01, the human-beta-2 microglobulin, and the human CD8-alpha molecule," scientists writing in the British Journal of Cancer report.
"Intranasal administration of GC90/IRIV resulted in the induction of a PTH-rP-specific multiepitope cytotoxic T-cell (CTL) response," said Antonio Scardino at INSERM U487 in France and collaborators in France, Italy, and Switzerland. "Cytotoxic T cells derived from vaccinated mice were capable of lysing in vitro syngenic murine PTH-rP transfectants and human HLA-A* 02.01+/PTH-rP+ ...
- Parathyroid hormone related protein and hypercalcaemia in breast cancer.
- Magazine article from: British Medical Journal Bundred, N.J. Ratcliffe, Wendy A. Walker, Rosemary A. Coley, S. Morrison, J.M. Ratcliffe, J.G. December 14, 1991 700+ words
...Abstract Objective--To see whether parathyroid hormone related protein has a humoral role...concentrations and tumour expression of parathyroid hormone related protein were determined...Subjects--Plasma concentrations of parathyroid hormone related protein were measured in...
- Recombinant human parathyroid hormone: osteoporosis is proving amenable to...
- Magazine article from: British Medical Journal Reeve, Jonathan February 23, 2002 700+ words
...for the use of recombinant human parathyroid hormone in the treatment of postmenopausal...voted unanimously in favour of the parathyroid hormone and approval could be expected after...partly based on solid evidence that parathyroid hormone, given as a daily injection for...
- Bone density parathyroid hormone and 25-hydroxyvitamin D concentrations in...
- Magazine article from: British Medical Journal Khaw, Kay-Tee Sneyd, Mary-Jane Compston, Juliet August 1, 1992 700+ words
...of calcium metabolism including parathyroid hormone and 25-hydroxyvitamin D concentrations...inversely related to serum intact parathyroid hormone concentrations and positively related...density and 25-hydroxyvitamin D and parathyroid hormone concentrations within the normal...
- Parathyroid hormone and alendronate offer no improved osteoporosis...
- Newspaper article from: Clinical Oncology Alert November 1, 2003 700+ words
Parathyroid hormone and alendronate in combination...alendronate 10 mg/d, 27 received parathyroid hormone 40 [micro]g subcutaneously...most effective treatment was parathyroid hormone alone (P < 0.001 for...
- Seasonal variation in 25-hydroxycitamin D and parathyroid hormone...
- Magazine article from: Age and Ageing Hegarty, Verona Woodhouse, Peter Khaw, Kay-Tee November 1, 1994 700+ words
...serum 25-hydroxyvitamin D and parathyroid hormone concentration was examined longitudinally...summer (35.4 mmol/l); mean parathyroid hormone concentration was highest in winter...significant (p < 0.0001). Parathyroid hormone concentrations were inversely related...
- Effect of parathyroid hormone (1-34) on fractures and bone mineral density in...
- Magazine article from: Physical Therapy Bookstein, Nancey A December 1, 2001 700+ words
...administration influences the effect of parathyroid hormone, which is known to stimulate both...study evaluated the effect of daily parathyroid hormone injections on women who were postmenopausal...or 40 [micro]g (n=552) of parathyroid hormone (1-34) by daily self-administered...
- Parathyroid Hormone Yields Big Cut in Fracture Risk.
- Magazine article from: OB GYN News JANCIN, BRUCE September 1, 2000 700+ words
...self-injection of recombinant parathyroid hormone dramatically reduced the risk of...placebo, 20 [micro]g recombinant parathyroid hormone (rPTH), or 40 [mirco]g rPTH...s investigational recombinant parathyroid hormone is composed of the first 34 amino...
- Emisphere Receives Patent Covering Oral Parathyroid Hormone Composition With...
- Press release article from: PR Newswire June 14, 2001 700+ words
...6,242,495 covering its oral parathyroid hormone (PTH) compositions and dosage...agent. A recombinant form of human parathyroid hormone (1-34), Forteo(TM) (teriparatide...delivery technology in combination with parathyroid hormone, will provide Emisphere and our...
- Nastech Pharmaceutical Company Announces Issuance of Patents for Parathyroid...
- Press release article from: PR Newswire July 17, 2007 700+ words
...patents relate to the Company's Parathyroid Hormone Nasal Spray for treatment of osteoporosis...for Enhanced Mucosal Delivery of Parathyroid Hormone," and PYY Nasal Spray for treatment...directed to aqueous formulations of parathyroid hormone and excipients with a specified...
- Recombinant human parathyroid hormone.(Letter to the Editor)
- Magazine article from: British Medical Journal Kuijpers, Gemma Schneider, Bruce Stadel, Bruce Colman, Eric May 18, 2002 700+ words
...s editorial on recombinant human parathyroid hormone. (1) Although the administration...1) Reeve J. Recombinant human parathyroid hormone. BMJ 2002;324:435-6. (23...2000 patients treated so far with parathyroid hormone or parathyroid hormone related protein...
Source: HighBeam Research, Vaccine for tumors secreting parathyroid hormone-related protein...