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Infection of macaques with SIV induces species-specific antibody response.
2003 SEP 10 - (NewsRx.com & NewsRx.net) -- Infection of macaques with simian immunodeficiency virus induces a species-specific antibody response to major histocompatibility complex class I and class II molecules.
According to a study from England, "Envelopes of retroviruses, including human immunodeficiency virus and simian immunodeficiency virus (SIV), contain host cell proteins that potentially represent novel targets for vaccine development. We show here that sera from rhesus macaques recognized simian major histocompatibility complex (MHC) molecules in response to infection with SIV."
"Antibodies from these animals did not cross-react with human MHC antigens on mitogen-activated peripheral blood mononuclear cells," said Natasha Polyanskaya and colleagues at the Centre for Applied Microbiology and Research (CAMR). "The development of antibodies to MHC class I alpha-chain did not correlate with anti-SIV envelope antibody responses, suggesting that these antibodies did not arise through molecular mimicry. In contrast to the species-specific response in infected animals, ...
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Source: HighBeam Research, Infection of macaques with SIV induces species-specific antibody...