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Peptide-loaded DCs prime T cells better than loaded cross-presenting DCs.
2003 SEP 10 - (NewsRx.com & NewsRx.net) -- Peptide-loaded dendritic cells prime and activate MHC-class I-restricted T cells more efficiently than protein-loaded cross-presenting dendritic cells.
According to a study from Denmark, "Undifferentiated and differentiated dendritic cells (uDC and dDC, respectively), derived from the bone marrow, were studied in vitro and in vivo. Ovalbumin (OVA) and two OVA-derived peptides binding to H-2K[superscript]b and 1-A[superscript]b, respectively, were used. Two IL-2 secreting T cell hybridomas specific for the OVA-derived epitopes were used in the in vitro read-out."
"The ability to cross-present the H-2K[superscript]b binding OVA[subscript]2577-264-peptide (SIINFEKL) was restricted to dDC, which express CD11c+, CD86+, and MHC-II+," reported Ozcan Met and colleagues at the University of Copenhagen. "In vitro, the antigenicity of SIINFEKL-loaded DC declined at a slower rate than that of OVA-pulsed DC. Moreover, SIINFEKL-loaded DC were up to 50 times more efficient than DC-pulsed with OVA-protein for generation of an H-2K[superscript]b-restricted response. Immunization ...
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Source: HighBeam Research, Peptide-loaded DCs prime T cells better than loaded cross-presenting...