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Epitope of SARS-coronavirus nucleocapsid protein identified.
2003 SEP 10 - (NewsRx.com & NewsRx.net) -- An epitope of the SARS-coronavirus nucleocapsid protein has been identified.
"The nucleocapsid (N) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) is a major virion structural protein. In this study, two epitopes (N1 and N2) of the N protein of SARS-CoV were predicted by bioinformatics analysis. After immunization with two peptides, the peptides-specific antibodies were isolated from the immunized rabbits," scientists in the People's Republic of China report.
"The further experiments demonstrated that N1 peptide-induced polyclonal antibodies had a high affinity to bind to E. coli-expressed N protein of SARS-CoV," stated Y. Lin and colleagues at the Chinese Academy of Sciences. "Furthermore, it was confirmed that N1 peptide-specific IgG antibodies were detectable in the sera of severe acute respiratory syndrome (SARS) patients. The results indicated that an epitope of the N protein has been ...
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- Epitope of SARS-coronavirus nucleocapsid protein identified.
- Newspaper article from: Proteomics Weekly September 8, 2003 700+ words
...expressed N protein of SARS-CoV," stated Y. Lin and colleagues at the Chinese Academy of Sciences. "Furthermore...respiratory syndrome (SARS) patients. The results...Identification of an epitope of SARS-coronavirus nucleocapsid...Biological Sciences, Chinese Academy of ...
