AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Transcriptional and transductional targeting improve gene delivery to ovaries.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Transcriptional and transductional targeting improve gene delivery to the ovaries.
"Adenoviruses are efficient gene delivery vehicles but have broad native tropism. To this end, finding ways to target this virus specifically to carcinomas has become an important focus of cancer gene therapy. Transductional and transcriptional forms of targeting have been used with promising results in ovarian carcinoma," researchers in Finland report.
"Therefore, we combined both forms of targeting to investigate the effect on the specificity and efficiency of transgene expression in this disease. We used the tissue-specific SLPI promoter and the ovarian cancer associated targeting adaptor protein, sCARfC6.5," wrote S.D. Barker and colleagues, University of Helsinki, Biomedicum Helsinki.
"This bispecific protein contains the coxsackie-adenovirus receptor ectodomain and a single-chain antibody specific for c-erbB-2. Viruses containing the SLPI or the ubiquitously expressed CMV promoter, with or without sCARfC6.5, were used for infection of ovarian cancer cell lines, primary ovarian tumor cells, and in an orthotopic model of disseminated ovarian carcinoma."
"This dual-targeting strategy increased the efficiency and specificity of transgene expression in ...
- GeneMedicine Receives Broad Gene Therapy Patents for Gene Delivery to Joints...
- Press release article from: Business Wire August 25, 1998 700+ words
...the inner ear. Gene therapy to joints may...The patent "Gene Therapy Using the Intestine...340) claims gene delivery to the intestines...of non-viral gene therapy products designed...peptide-based gene delivery systems, each...
- Tosk Develops Improved Gene Therapy Vector, Achieves Targeted Gene Delivery in...
- Press release article from: Business Wire August 12, 2002 700+ words
...transposon-based gene delivery, Tosk announced...performs targeted gene delivery when administered...applications such as gene therapy. "Our experiments...barriers to human gene therapy," Fogarty concluded...conference "Gene Delivery -- Nonviral...
- GENE THERAPY: Naked Gene Delivery Service.(Brief Article)
- Newspaper article from: Applied Genetics News March 1, 2000 700+ words
...the HGS proprietary genomics database for gene-based product development. HGS has the option to license Vical's DNA gene delivery technology for use in up to three gene-based products. In addition, Vical is granting an exclusive, royalty- bearing...
- GenStar Therapeutics Initiates Phase I Gene Therapy Clinical Trial for...
- Press release article from: Business Wire June 18, 2001 700+ words
...initiated a Phase I gene therapy clinical trial...GenStar's viral gene delivery system, MAXIMUM...developed this gene delivery platform from...developing innovative gene therapy products for...utilizing advanced gene delivery technologies...
- Intradigm Strengthens Scientific Capabilities Through Exclusive Access To New...
- Press release article from: PR Newswire February 1, 2002 700+ words
...exploit its proprietary gene delivery technologies both in...extensive toolbox of gene delivery capabilities which...expertise to support gene therapy companies in the development of their gene delivery needs. Investors include...
- Study tracks genes in murine embryos after gene delivery in mothers.(gene...
- Magazine article from: Women's Health Weekly December 5, 2002 700+ words
...fetuses in utero with gene therapy. Murine model experiments...mediated delivery of gene therapy to embryos that have...promising tool in fetal gene therapy and embryological studies...lineage of embryos after gene delivery via intravenous injection...
- Gene therapy escapes the immune response. (new gene delivery method)(Science...
- Magazine article from: Science News Travis, John September 2, 1995 700+ words
Lately, enthusiasm over gene therapy has given way to skepticism. The...quickly to start human trials of gene therapy. As this reflection goes on...continue to challenge the barriers to gene therapy's success. According to a report...
- Genetronics Scientists Present at First NIH Cutaneous Gene Therapy Conference;...
- Press release article from: PR Newswire April 13, 2000 700+ words
...the first cutaneous gene therapy conference have reported...skin make cutaneous gene delivery potentially useful...to other methods of gene delivery. Dr. Zhang will be...electroporation into gene therapy. Electroporation involves...
- GenVec, Inc. Announces Patent of Improved Gene Delivery Vectors For Use in Gene...
- Press release article from: PR Newswire February 18, 1999 700+ words
...vectors) for use in gene therapy applications. Some...effective manufacture of gene therapy products utilizing...commercialization of novel gene therapy products for major...combines GenVec's gene delivery technology and the...
- Press Release: Intradigm strengthens scientific capabilities through exclusive...
- News wire article from: Chemical Business Newsbase February 1, 2002 700+ words
...Prof A James Mixson that include highly effective and novel gene delivery polymers and all applications of synthetic vectors to cancer...therapies. Intradigm Corp is exploiting its proprietary gene delivery technologies both in the validation and discovery of drug...
Source: HighBeam Research, Transcriptional and transductional targeting improve gene delivery to...