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Therapy that prevents bone loss also reverses cholesterol transport.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Therapy that prevents bone loss also reverses cholesterol transport.
According to recent research from Germany, "nitrogen-containing bisphosphonates used in osteoporosis act by interference with pyrophosphorylated intermediates of the sterol pathway and are internalized by monocytes/macrophages, key players in atherogenesis. We therefore studied the effects of ibandronate on monocytic cholesterol homeostasis."
"In differentiated human MM6 cells and freshly prepared human peripheral blood monocyte cells (PBMCs) lipoprotein receptor transcription was quantified by real-time RT-PCR and receptor-mediated cellular cholesterol handling by lipoprotein-driven uptake and efflux assays," wrote D. Strobach and colleagues, University of Munchen Clinic.
"Low nanomolar concentrations of ibandronate reduced cellular cholesterol content despite reactive up-regulation of the LDL receptor. Simultaneously, the transcription of the cellular cholesterol exporter ABCA1 was several-fold stimulated, whereas the scavenger receptor CD36 was down-regulated. Thereby, ibandronate decreased the cellular uptake of modified LDL and enhanced the ...
- Mechanisms for cellular cholesterol transport: defects and human...
- Magazine article from: Physiological Reviews Ikonen, Elina October 1, 2006 700+ words
...Overview of Intracellular Cholesterol Transport A. Ports of sterol...uptake B. Endosomal cholesterol transport C. Cholesterol efflux...mobility IV. Cellular Cholesterol Transport: Lessons From Mouse...
- Colesevelam HCl decreases atherosclerosis and may activate reverse cholesterol...
- Magazine article from: Journal of Applied Research Davidson, Michael H. Dittakavi, Vani Bandari, Armin Davidson, David J. Maki, Kevin C. Subbaiah, Papasani V. March 1, 2006 700+ words
...aortic plaque area, and reverse cholesterol transport enzymes and genes in a rabbit model...potentially by enhancing reverse cholesterol transport, mediated by changes in LXR...liver X receptor (LXR), reverse cholesterol transport INTRODUCTION Bile acid sequestrants...
- Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for...
- Press release article from: PR Newswire November 5, 2007 700+ words
...that creates a defect in reverse cholesterol transport in patients with Diabetes Mellitus...functionality and the process of reverse cholesterol transport. The study is being presented...HDL oxidation and restore reverse cholesterol transport function," said Noah Berkowitz...
- AstraZeneca and AVANIR Announce Global Alliance to Discover and Develop Novel...
- Press release article from: Business Wire July 11, 2005 700+ words
...develop and commercialise Reverse Cholesterol Transport (RCT) enhancing compounds for...natural process known as Reverse Cholesterol Transport. Compounds that enhance this pathway...for dyslipidaemia, and Reverse Cholesterol Transport is an exciting therapeutic area...
- Jefferson Scientists Unlocking Secrets of Cholesterol Transport in Body.
- News wire article from: Ascribe Higher Education News Service February 23, 2004 700+ words
...of an unidentified cholesterol transport system in the intestine...mechanisms behind cholesterol transport and absorption in...the existence of a cholesterol transport system in the intestines...
- Jefferson scientists unlocking secrets of cholesterol transport in body.
- Newspaper article from: Proteomics Weekly March 15, 2004 700+ words
...of an unidentified cholesterol transport system in the intestine...mechanisms behind cholesterol transport and absorption in...the existence of a cholesterol transport system in the intestines...
- Colesevelam, atherosclerosis, and reverse cholesterol...
- Magazine article from: Journal of Applied Research Toth, Peter P. March 1, 2006 700+ words
...with therapies that augment reverse cholesterol transport. Reverse cholesterol transport (RCT) is the process by which high...referred to as "indirect reverse cholesterol transport'; and SRBI mediates the selective...
- KineMed Presents Data Measuring Changes in Reverse Cholesterol Transport for...
- Press release article from: PR Newswire May 10, 2007 700+ words
...through the pathway known as reverse cholesterol transport (RCT). RCT is the only known...Cholesterol Efflux and Global Reverse Cholesterol Transport Rates in Vivo with Stable Isotopes...titled, -- "Measuring Reverse Cholesterol Transport and Insulin-Mediated Glucose...
- KineMed Presents Innovative Measurement of Reverse Cholesterol Transport at the...
- Press release article from: PR Newswire November 15, 2005 700+ words
...for the Measurement of Reverse Cholesterol Transport" will be presented in the session...Hall E. Background on reverse cholesterol transport Higher plasma concentrations of...of HDLc is its role in reverse cholesterol transport (RCT). This refers to the process...
- Phase I Reverse Cholesterol Transport Trial Initiated; AVANIR to Receive $5...
- Press release article from: Business Wire January 3, 2006 700+ words
...of AZD2479, a compound under development as a reverse cholesterol transport enhancer. The allowance of the investigational new drug...strong balance sheet as we move into 2006." Reverse cholesterol transport, or RCT, is a natural process that involves the flow...
Source: HighBeam Research, Therapy that prevents bone loss also reverses cholesterol transport.