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Leptin and hCG modulate new vessel growth at the maternal/fetal interface.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Leptin and hCG modulate new vessel growth at the maternal/fetal interface.
According to published research from Switzerland, "vascular endothelial growth factor (VEGF) has been identified as an endothelium-specific mitogen and inducer of angiogenesis and endothelial cell survival. Leptin and hCG have also been suggested as possible regulators of angiogenesis in various models. In-vivo and in-vitro assays revealed that leptin has an angiogenic activity and that the vascular endothelium is a target for leptin."
"Thus, we hypothesized that products of cytotrophoblastic cells may play a role in placental angiogenesis and we therefore investigated the effects of leptin and hCG on cytotrophoblast VEGF secretion. We incubated cytotrophoblastic cells (CTB) with recombinant human leptin (rhLept) (0-4 pg/ml) or hCG (0-30 000 IU/ml) for 4 hours," said D. Islami and colleagues, University of Geneva, Cantonal Hospital.
"RhLept significantly stimulated hCG (P=0.0045) and decreased VEGF release (P=0.0008) by CTB in a concentration-dependent manner. On the other hand, increasing concentrations of hCG (0-30,000 IU/ml), induced a significant inhibition of leptin secretion (P=0.0028) and a marked dose-dependent stimulation of VEGF(165) secretion (P
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- Leptin enhances secretory activity of regenerating rat adrenal cortex.
- Newspaper article from: Biotech Week March 3, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Leptin enhances the secretory activity and inhibits...According to recent research from Italy, "Leptin, an adipose tissue-secreted hormone...may variously interact with the native leptin molecule and its fragments. Evidence...
- Leptin resistance in obesity related to defects in leptin signaling pathways.
- Newspaper article from: Biotech Week March 31, 2004 700+ words
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Leptin resistance in obesity is related to defects in leptin signaling pathways. "Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one...
- Leptin Genotype Is Associated with Lactation Performance and Health of Holstein...
- Magazine article from: Journal of Dairy Science Chebel, R C; Susca, F; Santos, J E P July 1, 2008 700+ words
...SNP) in the R4C locus in exon 2 of the leptin gene and the lactational performance and...had their DNA sequenced in exon 2 of the leptin gene to determine the presence of SNP...02) and T (3.04 0.03) alleles. Leptin genotype was associated with yields of...
- LEPTIN BREAKS OUT OF BRAIN BOX APPETITE-BLOCKING PROTEIN, RECEPTOR ALSO SUPPLY...
- Magazine article from: BIOWORLD Today September 11, 1998 700+ words
...named their anti-obesity molecule leptin. (See BioWorld Today, Dec. 1, 1994, p. 1.) Unsurprisingly, leptin has since been the subject, and object...effortless weight reduction may come true. Leptin has since shown that, besides putting...
- Leptin has differential effects on monocyte ROS activity during HIV infection.
- Newspaper article from: Immunotherapy Weekly January 21, 2004 700+ words
...oxidative activity is differentially influenced by leptin in HIV patients and healthy individuals. "Leptin, the 16-kDa product of the ob gene, is...Spain. "However, the physiological role of leptin is not limited to the regulation of food intake...
- Leptin is a significant regulator of bone mass.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Leptin is a significant regulator of bone mass...to a study from the United States, "leptin is a powerful inhibitor of bone formation...This antiosteogenic function involves leptin binding to its receptors on ventromedial...
- Leptin fails as a therapy to prevent weight regain.
- Newspaper article from: Biotech Week March 26, 2003 700+ words
...Food-deprived rats that were given leptin ate less compared with control rats that did not receive leptin, but regained weight to an extent similar...Australia. "We tested the proposition that leptin is used as a signal by the brain to regulate...
- Leptin genotype shows snag in DNA markers.(Nutrition & Health: Beef)
- Magazine article from: Feedstuffs Bradford, Barry September 19, 2005 700+ words
...least one test, there may be an additional complication for MAS. Leptin marker A marker is now available for a polymorphism in the leptin gene (Buchanan et al., 2002). Leptin is a hormone produced by fat cells, and as an animal deposits fat...
Source: HighBeam Research, Leptin and hCG modulate new vessel growth at the maternal/fetal...