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Cyclin E is overexpressed and amplified in many different human tumor types.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Cyclin E is overexpressed and amplified in many different human tumor types.
According to published research from Switzerland, "Cyclin E amplification and overexpression have recently been described in several tumor types. However, many tumor entities have never been examined for cyclin E alterations.
"Numerous and time-consuming experiments were previously required to determine the significance of potential oncogenes across different tumor types," wrote P. Schraml and colleagues, University of Basel Hospital, Pathology Institute.
"To overcome this problem, tissue microarrays (TMAs) consisting of 3670 primary tumors from 128 different tumor types, 709 metastases, and 354 normal tissues were generated," the researchers wrote.
"Cyclin E alterations were then analyzed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC)," they stated.
"Cyclin E gene amplification was observed in 15 different tumor types and subtypes, i.e., rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medullary breast cancer, gall bladder adenocarcinoma, pheochromocytoma, ...
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- Magazine article from: BIOWORLD Today Osborne, Randall April 29, 2005 700+ words
...Editor Sunesis Pharmaceuticals Inc. in-licensed the Phase I cyclin- dependent kinase inhibitor BMS-38702 from Bristol-Myers...BioWorld Today, Dec. 28, 2004.) Phase II studies in multiple tumor types are set to begin in the second half of the year, along with...
- Cyclin-dependent kinase 2 activated by cyclin E in breast cancer cells.
- Magazine article from: Women's Health Weekly June 3, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase 2 is activated by...length and low molecular weight forms of cyclin E in breast cancer cells. According to a study from the United States, "Cyclin E, a positive regulator of the cell...
- Cyclin E and Survival in Patients with Breast Cancer.
- Newspaper article from: Clinical Oncology Alert January 1, 2003 700+ words
Cyclin E and Survival in Patients with Breast Cancer Abstract...for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3 to about 8 times as high as the hazard...
- Cyclin A1 is expressed at different levels in many tumors.
- Newspaper article from: Cancer Weekly April 8, 2003 700+ words
2003 APR 8 - (NewsRx.com & NewsRx.net) -- Cyclin A1 is expressed at different levels in many tumors. "Cyclin A1 is a tissue-specific A-type cyclin that is essential for spermatogenesis. Overexpression of cyclin A1...
- Cyclin D1 Expression in Dysplastic Nevi: An Immunohistochemical Study.
- Magazine article from: Archives of Pathology & Laboratory Medicine Ewanowich, Carol Brynes, Russell K. Medeiros, L. Jeffrey McCourty, Althea Lai, Raymond February 1, 2001 700+ words
...During the cellular proliferative state, the complex of cyclin D1 and cyclin-dependent kinases phosphorylates the retinoblastoma...of genes essential for S phase, including cdc25A, cyclin E, and B-myb.[2] This pathway is negatively...
- Cyclin E overexpression in some cancers means proliferation and poor prognosis.
- Newspaper article from: Biotech Week March 24, 2004 700+ words
...According to a study from Germany, "Cyclin-dependent kinase (CDK)2 interacting...role in the pathogenesis of cancer." "Cyclin A2 is associated with cellular proliferation...a proliferation marker. In addition, cyclin A2 expression is associated with a poor...
- Cyclin A may be immunological signal toward proliferation, progression of...
- Newspaper article from: Cancer Weekly February 11, 2003 700+ words
...According to recent research from Japan, "Cyclin A is a protein kinase acting a pivotal...significance of immunohistochemical expression of cyclin A in superficial squamous cell carcinoma...esophagus. Immunohistochemical staining of cyclin A was performed on 45 samples of esophageal...
- Effects of p53 on KSHV cyclin-induced lymphomagenesis clarified.
- Newspaper article from: AIDS Weekly March 15, 2004 700+ words
...amp; NewsRx.net) -- The effects of p53 on KSHV cyclin-induced lymphomagenesis have been characterized...sarcoma-associated herpesvirus (KSHV) encodes a cyclin D homolog, K cyclin, that is thought to promote viral oncogenesis...
Source: HighBeam Research, Cyclin E is overexpressed and amplified in many different human tumor...