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HIV nef gene linked to vertical transmission.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- The HIV nef gene appears to play a key role in mother-to-child transmission of the virus.
HIV nef "is conserved among members of human and simian immunodeficiency viruses and may play an important role in viral pathogenesis," scientists in the United States explained."
"To determine the evolutionary dynamics and conservation of functionality" of HIV nef "during maternal-fetal transmission," T. Hahn and colleagues at the University of Arizona "analyzed nef sequences from seven mother-infant pairs following perinatal transmission, including a mother with infected twin infants."
"The nef open reading frame was maintained in mother-infant isolates with a frequency of 86.2% following vertical transmission," they wrote in the Journal of Biomedical Science.
"While there was a low degree of viral heterogeneity and estimates of genetic diversity and high population growth rates of nef sequences from mother-infant isolates, the infants' nef sequences were slightly higher with respect to these parameters compared with the mothers' sequences," study data indicated. "Both the mothers' and infants' nef sequences were under positive selection pressure, as determined by a new method of Nielsen and Yang [Genetics 148:929936;1998]."
"Based on genetic distance and phylogenetic parameters, the epidemiologically linked nef sequences from mother-infant pairs were closer to each other compared with ...
- HIV Nef inhibits T cell migration.
- Newspaper article from: Proteomics Weekly February 3, 2003 700+ words
...shed new light on the activity of the HIV Nef protein. This regulatory protein "has...to better characterize the effects of HIV Nef on T cell function by examining chemotaxis...signaling molecules." They found that "HIV Nef inhibited chemotaxis in response to SDF...
- HIV Nef induces accumulation of MHC II complexes and MVBs.
- Newspaper article from: AIDS Vaccine Week January 12, 2004 700+ words
2004 JAN 12 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein induces the accumulation of MHC II complexes and MVBs. "Nef alters the cell surface expression of several immunoreceptors...
- HIV Nef induces DC differentiation through Vav signaling.
- Newspaper article from: Drug Week January 16, 2004 700+ words
2004 JAN 16 - (NewsRx.com & NewsRx.net) -- HIV Nef induces DC differentiation through Vav-mediated signaling. "The accessory HIV-1 Nef protein plays a key role in AIDS pathogenesis...
- HIV Nef-mediated MHC-I downmodulation is independent of Arf6 activity.
- Newspaper article from: AIDS Weekly February 16, 2004 700+ words
...FEB 16 - (NewsRx.com & NewsRx.net) -- Nef-induced MHC-I downregulation does not depend on Arf6 activity. "HIV Nef has a number of important biological effects, including the downmodulation of several immunological important molecules (CD4...
- HIV Nef activates macrophage STAT3 via soluble factors.
- Newspaper article from: Drug Week February 13, 2004 700+ words
2004 FEB 13 - (NewsRx.com & NewsRx.net) -- HIV Nef activates macrophage STAT3 via soluble factor activity. According to a study from Italy, "Increasing evidence indicates that...
- HIV Nef uses soluble factors to activate macrophage STAT3.
- Newspaper article from: Drug Week April 30, 2004 700+ words
2004 APR 30 - (NewsRx.com & NewsRx.net) -- HIV Nef activates monocyte/macrophage STAT3 by releasing soluble factors. "Increasing evidence indicates that the expression of the...
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- Press release article from: M2 Presswire March 5, 2009 700+ words
...Markets: An Introduction to Biomedical Science in Professional and Clinical...report "An Introduction to Biomedical Science in Professional and Clinical Practice" to their offering. Biomedical Science in Professional and Clinical...
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- Newspaper article from: Blood Weekly March 19, 2009 700+ words
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Source: HighBeam Research, HIV nef gene linked to vertical transmission.