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Oxytocin and estrogen receptor mRNAs change during the rodent estrous cycle.

Women's Health Weekly

| September 04, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Oxytocin and estrogen receptor mRNAs change during the rodent estrous cycle.

According to recent research published in the Journal of Veterinary Medical Science, "oxytocin receptor (OTR) mRNA levels increase dramatically near term and is potently stimulated by estrogen because increased OTR mRNA levels result from estrogen treatment in ovariectomized rat uterus. In this study, OTR, estrogen receptor (ER) alpha and ERbeta mRNA levels in the rat uterus during the estrous cycle were examined by quantitative RT-PCR."

"OTR mRNA levels during the estrous cycle began to increase on diestrus (P

"In contrast ERalpha mRNA levels began to decrease on diestrus, reached statistical significance both in the morning and the afternoon on proestrus (P

"ERbeta mRNA levels were low in the morning and the afternoon on proestrus (P

"It can be concluded from these results that during the estrous cycle, OTR mRNA levels in rat uterus predominantly increase at proestrus with a decrease in ERalpha and ERbeta mRNA levels, which is probably due to the increased estrogen levels in circulation before ovulation," scientists concluded.

Murata and colleagues published their study in Journal of Veterinary Medical Science ...

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