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Intermittent estrogen stimulates cell differentiation and bone formation.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Intermittent estrogen stimulates cell differentiation and bone formation.
"Although it is well established that estrogen inhibits bone resorption, its effects on bone formation remain controversial. We studied the effects of intermittent and continuous treatment with estrogen on bone formation in vitro using long term cultures of SaOS-2 cells under conditions that permit mineralization. SaOS-2 cells cultured in dexamethasone, ascorbic acid and beta-glycerophosphate for up to 17 days formed mineralized bone nodules as visualized by von Kossa staining," scientists writing in the journal Biological & Pharmaceutical Bulletin reported.
"Electron microscopic analysis of ultrathin sections of representative mineralized nodules showed the presence of mineral deposits, collagen fibrils and osteocytes. Both the mineralized nodule numbers and areas increased exponentially with time of culture after addition of beta-glycerophophate at day 8," wrote L.G. Rao and colleagues, St. Michaels Hospital, Division of Endocrinology and Metabolism.
"Intermittent addition of 17beta-estradiol (E-2) for 6 hours (h) or 24 h of every 48 h starting at day 3 or day 8 to the end of culture period resulted in a specific time- and dose-dependent stimulation of mineralized bone nodule number and area, and alkaline phosphatase activity which were ...
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Source: HighBeam Research, Intermittent estrogen stimulates cell differentiation and bone...