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Three immunohistochemical stains help distinguish clear cell cancer as ovarian or renal.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Three immunohistochemical stains can help distinguish clear cell carcinoma origin as ovarian or renal.
According to recent research published in the International Journal of Gynecological Pathology, "The diagnosis of primary clear cell carcinoma of the ovary or kidney is usually straightforward. However, problems in ascertaining the site of the primary tumor may arise when there is widespread metastatic disease or when clear cell carcinoma is present in both the ovary and kidney. In this study, the value of a panel of antibodies in distinguishing between an ovarian and renal clear cell carcinoma was evaluated.
"The panel comprised cytokeratins (CK) 7 and 26, vimentin, estrogen receptor (ER), CD10, and renal cell carcinoma (RCC) marker. Ovarian clear cell carcinomas (n=14) were positive with CK7 (14/14), vimentin (6/14), ER (2/14), and RCC marker (2/14). All were negative for CD10 and CK20.
"Renal clear cell carcinomas (n=14) were positive with CD10 (14/14), RCC marker (14/14), vimentin (7/14), CK7 (2/14), and CK20 (1/14). All were negative with ER. This panel allows clear cell carcinomas of the ovary and kidney to be ...
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Source: HighBeam Research, Three immunohistochemical stains help distinguish clear cell cancer...