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IL-6 fused to antibody increases immune response against ovarian cancer.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Interleukin-6 fused to an anti-idiotype antibody in a vaccine increases the specific humoral immune response against CA125+ (MUC-16) ovarian cancer
"Anti-idiotypic (Id) monoclonal antibodies can serve as surrogate for tumor-associated antigens in vaccination strategies. The murine anti-Id monoclonal antibody ACA125 that mimics the CA125 carbohydrate antigen expressed on ovarian cancer cells induces an anti-anti-Id antibody (Ab3) response that is associated with prolonged survival of ovarian cancer patients," scientists in Germany report.
"To increase the Ab3 antibody response, we evaluated two strategies in a mouse model: co-injection of human interleukin (IL)-6 together with the fusion protein chACA125, which consists of the anti-Id ACA125 single-chain Fv antibody joined to the human IgG1 CH2/CH3 domain; and injection of the fusion protein chACA125-IL-6, which consists of the ACA125 single-chain Fv fused to human IL-6 via the IgG1 CH2/CH3 domain," stated Silke Reinartz at the University of Marburg and collaborators throughout Germany. "Vaccination of mice with the chACA125-IL-6 fusion protein resulted in higher titers of anti-CA125 (Ab3) antibodies compared with application of the chACA125 antibody with or without systemic co-administration of IL-6."
The investigators found, "Application of the chACA125-IL-6 fusion protein did not elicit ...
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