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Systemic redundancies may mask the effects of PAI-1 on cancer inactivation.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Systemic redundancies may mask the effects of PAI-1 on cancer inactivation.
"The plasminogen activator inhibitor-1 (PAI-1) blocks the activation of plasmin(ogen), an extracellular protease vital to cancer invasion. PAI-1 is like the corresponding plasminogen activator uPA (urokinase-type plasminogen activator) consistently expressed in human breast cancer. Paradoxically, high levels of PAI-1 as well as uPA are equally associated with poor prognosis in cancer patients," scientists in Denmark report.
"PAI-1 is thought to play a vital role for the controlled extracellular proteolysis during tumor neovascularization. We have studied the effect of PAI-1 deficiency in a transgenic mouse model of metastasizing breast cancer. In these tumors, the expression pattern of uPA and PAI-1 resembles that of human ductal breast cancer and plasminogen is required for efficient metastasis," according to K. Almholt and colleagues, Finsen Laboratory.
"In a cohort of 63 transgenic mice that were either PAI-1-deficient or wild-type sibling controls, primary tumor growth and vascular density were unaffected by PAI-1 status. PAI-1 deficiency ...
- Regulation of plasminogen activator inhibitor 2 (PAI-2) by Helicobacter pylori:...
- Magazine article from: Gut Varro, A. Noble, P.J.M. Pritchard, D.M. Kennedy, S. Dimaline, R. Hart, C.A. Dockray, G.J. April 1, 2004 700+ words
...stimulates gastric expression of plasminogen activator inhibitor (PAI)-2. The latter inhibits urokinase plasminogen activator and is increased in gastric adenocarcinoma...have examined H pylori induction of PAI-2 and the effects on cell invasion...
- PAI-1 is a critical upstream regulator of the TGF-[beta]1/EGF-induced invasive...
- Magazine article from: Journal of Biomedicine and Biotechnology Wilkins-Port, Cynthia E. Higgins, Craig E. Freytag, Jennifer Higgins, Stephen P. Carlson, J. Andrew Higgins, Paul J. January 1, 2007 700+ words
...critical in triggering downstream MMP activity. Paradoxically, PAI-1, the major physiological inhibitor of plasmin generation...promote epithelial cell plasticity and tissue invasion. Increased PAI-1 expression serves to temporally and spatially modulate plasmin...
- Association between plasma concentrations of plasminogen activator inhibitor-1...
- Magazine article from: British Medical Journal Nielsen, Hans Jorgen Pappot, Helle Christensen, Ib Jarle Brunner, Nils Thorlacius-Ussing, Ole Moesgaard, Flemming Dano, Keld Grondahl-Hansen, Jan March 14, 1998 700+ words
...Riccio A, Stacey SN. Plasminogen activator inhibitors: hormonally...level of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts...Plasminogen activators and plasminogen activator inhibitors in blood and...
- Plasminogen activator inhibitor-1 protein blocks growth factor isoforms.
- Newspaper article from: Angiogenesis Weekly February 21, 2003 700+ words
...truncated form of plasminogen activator inhibitor can...of the porcine plasminogen activator inhibitor-1 (PAI-1) gene to...functions of the PAI-1 isoforms...bind urokinase plasminogen activator and plasminogen...
- Angiogenesis and plasminogen activator inhibitor type I are cancer predictors.
- Newspaper article from: Angiogenesis Weekly April 18, 2003 700+ words
...Angiogenesis and plasminogen activator inhibitor type...the levels of plasminogen activator inhibitor type I (PAI-I) are both...prognostic impact of PAI-I is not only...the level of plasminogen activator inhibitor type...
- Angiogenesis and plasminogen activator inhibitor type I are cancer...
- Magazine article from: Women's Health Weekly April 17, 2003 700+ words
...Angiogenesis and plasminogen activator inhibitor type...the levels of plasminogen activator inhibitor type I (PAI-I) are both...prognostic impact of PAI-I is not only...the level of plasminogen activator inhibitor type...
- Reducing plasminogen activator inhibitor-1 is potential diabetes therapy.
- Newspaper article from: Drug Week February 27, 2004 700+ words
...Reducing plasminogen activator inhibitor-1...Concentrations of plasminogen activator inhibitor-1 (PAI-1) are elevated...regulation of PAI-1, its activity...Medicine (Effect of plasminogen activator inhibitor-1...
- Urokinase-type plasminogen activator is prognostic in breast cancer.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...Urokinase-type plasminogen activator (UPA) and...Urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-I, play a...determination of uPA and PAI-I in primary...Urokinase-type plasminogen activator (UPA) and...
- Chemotherapy in N0 Breast Cancer Patients by Urokinase-type Plasminogen...
- Newspaper article from: Clinical Oncology Alert September 1, 2001 700+ words
...according to tumor levels of uPA and PAI-1 and then randomized them to...tumor levels of urokinase-type plasminogen activator (uPA) and its inhibitor, plasminogen activator inhibitor type 1 (PAI-l), were prognostic factors...
- Blood substances linked to heart risk. (low levels of plasminogen activator...
- Magazine article from: Science News Fackelmann, Kathy A. November 20, 1993 700+ words
...colleagues focused on a substance in the blood called plasminogen activator inhibitor (PAI). One of PAI's main duties in the blood stream is to block...The team discovered that concentration of PAI in the blood were lower in premenopausal women...
Source: HighBeam Research, Systemic redundancies may mask the effects of PAI-1 on cancer...