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Genes showing differential expression in anorexia mutant mouse identified.
2003 SEP 4 - (NewsRx.com & NewsRx.net) -- Genes showing differential expression in the anorexia mutant mouse model have been identified.
According to published research from South Korea, "Differential display (DID) PCR was applied to identify genes regulated by anorexia (anx) in mouse brain. Of the four apparently differentially expressed genes, three (H2-H4) had high homology with known genes such as apoptotic protease activating factor I (Apaf 1), adenylate cyclase 6 (Adcy 6), and myelin proteolipid protein (PLP). H1, designated as HIPA1, had a homology with unknown function gene fragments."
"Northern blot analysis confirmed HIPA1 expression induced by anorexia," reported Hong Sung Chun and colleagues at Chosun University. "A 1579 bp full-length cDNA of HIPA1 was isolated from a mouse brain cDNA library using a probe from the differentially displayed H1 fragment. Sequence analysis showed that HIPA1 had 98.7% homology to ...
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Source: HighBeam Research, Genes showing differential expression in anorexia mutant mouse...