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Implications of genetic traits on vaccine efficacy outlined.
2003 SEP 3 - (NewsRx.com & NewsRx.net) -- The implications of genetic traits on vaccine efficacy have been outlined in a recent issue of Statistics in Medicine.
"Literature on genetic screening in the community suggests that people having specific genotypes may either get or protect from infection, for example, malaria, human papillomavirus, and hemophilic influenza, for which vaccines are either already developed or being targeted. In such a situation, the evaluation of the efficacy of vaccine in the community needs to be examined with caution," a scientist in India reports.
"In this paper, I present a method for the estimation of vaccine efficacy (VE) in the presence of genetic traits/component (theta) and the sample size required to estimate the 95% confidence intervals (CI) with a given relative width for the estimated vaccine efficacy," said B. N. Murthy at the National Institute of Epidemiology in Tamil Nadu, India. "Considering true efficacy ranging from 40 to 80% and the possible values of the genetic component (theta) ranging from 0 to 60%, the VE was estimated. The 95% CI for the estimated VE for relative widths (R) 1.0 and 0.1 were computed. The sample sizes required for each of the unvaccinated and vaccinated cohorts were computed for estimating the 95% CI for given incidence rates in the unvaccinated (Iu) cohort."
"In the presence of genetic traits, I found that the VE was consistently overestimated," Murthy reported. "There existed change in the location as well as the asymmetry of the 95% CIs ...
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Source: HighBeam Research, Implications of genetic traits on vaccine efficacy outlined.