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Mixture of CpG oligodeoxynucleotides may be needed for effective vaccine.
2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A mixture of immunostimulatory CpG oligodeoxynucleotides (ODNs) may be needed to elicit a reliable immune response in most humans.
"Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger an immune response characterized by proliferation, B-cell activation, and cytokine production. CpG ODNs show promise in animal models as vaccine adjuvants and anti-allergens and for the treatment of infectious diseases and cancer. Several different CpG motifs capable of stimulating human cells have been identified, and several CpG-containing ODNs are now in various stages of clinical trials," researchers in the United States report.
"However, little is known of the comparative magnitude or breadth of the immune responses these CpG ODNs elicit," said Cynthia A. Leifer and colleagues at the Food and Drug Administration. "This work compares the proliferative, IgM, and IL-6 response of PBMCs from 100 normal donors to a panel of 11 ODNs selected as highly active from over 100 phosphorothioate ODNs. While PBMCs from every donor responded to at least one member of the ODN panel, no single ...
- CpG oligodeoxynucleotides find immunotherapeutic use.
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- Newspaper article from: Vaccine Weekly February 5, 2003 700+ words
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- Epicutaneous CpG oligodeoxynucleotides with antigen promotes CTL.
- Newspaper article from: Obesity, Fitness & Wellness Week July 10, 2004 700+ words
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- CpG oligodeoxynucleotides enhance immune response to herpesvirus vaccine.
- Newspaper article from: Virus Weekly February 11, 2003 700+ words
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- Vaccine elicits immune response against respiratory syncytial virus.
- Newspaper article from: Gene Therapy Weekly February 5, 2004 700+ words
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