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Nasal vaccine may increase protection.

Vaccine Weekly

| September 03, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 SEP 3 - (NewsRx.com & NewsRx.net) -- A vaccine administered through the nasal passages may increase protection against pneumococcal disease compared to the current vaccine, say researchers from Albany Medical College in New York and the University of Alabama at Birmingham.

Streptococcus pneumoniae, a common cause of bacterial pneumonia, generally enters the body through the nose. While the current intramuscular immunizations are effective in fighting the disease, their ability to protect against bacterial carriage in the nasal passages is only 50-60%.

In the study, published in Infection and Immunity, mice were immunized intranasally, treated with interleukin-12 to enhance mucosal immune response and then challenged with varying strains of S. pneumoniae. The researchers found a 75% survival rate of vaccinated mice as ...

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Source: HighBeam Research, Nasal vaccine may increase protection.

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