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Host cell binding prevented for cytomegalovirus coated with AD-2 antibody.
2003 SEP 3 - (NewsRx.com & NewsRx.net) -- Virus receptor binding was prevented when cytomegalovirus was coated with antibodies specific for antigenic domains 2.
According to a study from Germany and Sweden, "Attachment of, and cell-cell fusion induced by, human cytomegalovirus were studied in the presence of neutralizing monospecific antibodies against antigenic domains 1 (AD-1) or 2 (AD-2) of glycoprotein B (gB, gpUL55)."
"Efficient inhibition of the virion-mediated fusion event was consistently observed for the human AD-2-specific antibody as determined by a reporter gene activation assay based on permissive astrocytoma cells," reported Dorothee Gicklhorn and colleagues at Philipps-Universitat Marburg in Germany and Lund University in Sweden. "In contrast, antibodies directed against the major neutralizing gB epitope AD-1 reduced fusion only by 20-60%."
The researchers found, "Virus attachment via heparin sulfate was unaffected by the antibodies under the conditions used. Virus receptor binding as examined by heparin treatment of adsorbed virus was significantly reduced only if the virus had been coated ...
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Source: HighBeam Research, Host cell binding prevented for cytomegalovirus coated with AD-2...