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MUC1-derived glycopeptides are strong antigens for breast cancer vaccines.
2003 SEP 3 - (NewsRx.com & NewsRx.net) -- MUC1-derived glycopeptide libraries with improved MHC anchors are strong antigens and prime mouse T cells for proliferative responses to lysates of human breast cancer tissue
According to recent research from Denmark, "Multi-component glycopeptide libraries and single glycopeptides were used for immunization of mice with the aim of inducing strong T helper cell responses to the repetitive sequence of MUC1 expressed by human tumor cells. The glycopeptides and glycopeptide libraries were modeled upon the native human MUC1 amino acid variable number of tandem repeats sequence by introduction of modifications in the MHC anchor positions to optimally fulfill the binding requirements of the A[superscript]d MHC class II molecule in the BALB/c mouse."
"The immunogenicity of the MUC1 glycopeptides in BALB/c mice was determined by immunization in complete Freund's adjuvant and assaying lymph node T cells for a proliferative response to the glycopeptide used," reported Monika Gad and collaborators at the University of Copenhagen and The Carlsberg Laboratory. "Strong proliferative responses with stimulation indices over 50 were obtained with anchor-improved glycopeptide libraries as well as with single glycopeptides. Immunization with one of the glycopeptide libraries primed T cells for a proliferative cross-response to the native MUC1 glycopeptide, which by itself was nonimmunogenic."
"In addition, immunization with the same glycopeptide library primed T cells for a strong response to ...
- MUC1-derived glycopeptides are strong antigens for breast cancer vaccines.
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