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Proteasomal cleavage sites of proteins for cytotoxic T cells may soon be fully predictable.
2003 SEP 3 - (NewsRx.com & NewsRx.net) -- There are methods available for predicting where the proteasome will cut epitopes that get presented to cytotoxic T cells, but they are still not completely accurate.
According to recent research published in the journal International Immunology, "The proteasome plays an essential role in the immune responses of vertebrates. By degrading intercellular proteins from self and non-self, the proteasome produces the majority of the peptides that are presented to cytotoxic T cells (CTL).
"There is accumulating evidence that the C-terminal, in particular, of CTL epitopes is cleaved precisely by the proteasome, whereas the N-terminal is produced with an extension, and later trimmed by peptidases in the cytoplasm and in the endoplasmic reticulum. Recently, 3 publicly available methods have been developed for prediction of the specificity of the proteasome. Here we compare the performance of these methods on a large set of CTL epitopes," wrote P. ...
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