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Dendritic cell vaccine induces antigen-specific protective antitumor immunity.
2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity.
"In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine. Anti-idiotype 3H1 mimics a distinct and specific epitope of CEA and can generate anti-CEA immunity in mice, rabbits, monkeys, and humans when used with a conventional immune adjuvant. Our goal was to determine whether the use of DC as direct antigen-presenting cells would improve the potency of 3H1 as vaccine," scientists in the United States report.
"Bone marrow-DC pulsed with 3H1 and injected into naive mice induced both humoral and cellular anti-3H1, as well as anti-CEA immunity," stated Asim Saha and collaborators at the University of Cincinnati and Vanderbilt University. "Specific killing of C15 cells in in vitro antibody-dependent cellular cytotoxicity has been observed by immune sera. Immune-splenic lymphocytes when stimulated in vitro with 3H1 or CEA, showed increased proliferative CD4+ Th1 type T-cell response and secreted significantly high levels of Th1 cytokines [IFN-gamma, interleukin (IL)-2] and low levels of Th2 cytokines (IL-4, IL-10). This vaccine also induced MHC class I antigen-restricted CD8+ T-cell ...
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Source: HighBeam Research, Dendritic cell vaccine induces antigen-specific protective antitumor...