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CD80 and CD86 expression produces tumor vaccine better than either alone.
2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Dual expression of CD80 and CD86 produced a tumor vaccine superior to single expression of either molecule.
According to recent research from the United States, "A murine model for neuroblastoma, Neuro-2a (N2a), was used to establish a model tumor vaccine. An aggressive subclone of N2a and the less aggressive parental line were transfected with CD80, CD86, or both molecules and stable lines were established."
"The less aggressive N2a expressing either CD80 or CD86 induced anti-tumor immunity," reported Bryon D. Johnson and colleagues at the Medical College of Wisconsin in Milwaukee. "In contrast, dual expression of CD80 and CD86 was required to initiate a protective anti-tumor immune response against the aggressive subclone. Control of tumor growth was dependent on CD8+ lymphocytes that infiltrated dual-expressing (CD80 and CD86) lesions. These tumor-infiltrating lymphocytes (TIL) exhibited a non-classical mechanism of tumor cell lysis that may require both the up-regulation of cell surface molecules on the tumor and the ...
- CD80 and CD86 expression produces tumor vaccine better than either alone.
- Newspaper article from: Drug Week August 22, 2003 700+ words
...CD86 produced a tumor vaccine superior to...establish a model tumor vaccine. An aggressive...colleagues at the Medical College of Wisconsin...CD86 produces a tumor vaccine superior to...Oncology, Medical College of Wisconsin...
- Broadly applicable heat shock protein-mediated tumor vaccine developed.
- Newspaper article from: Immunotherapy Weekly January 14, 2004 700+ words
...shock protein-mediated oncolytic tumor vaccine. According to recent research from...to antigen-presenting cells, HSP tumor vaccine has been tested in clinical trials...developed a novel HSP-mediated oncolytic tumor vaccine, referred to as HOT vaccine, by combining...
- An Effective Tumor Vaccine Against Malignant Melanoma: Irradiated Autologous...
- Newspaper article from: Vaccine Weekly February 8, 1999 700+ words
...B.; Jezersek, B. "An Effective Tumor Vaccine Against Malignant Melanoma: Irradiated...as effective as possible autologous tumor vaccine which would be at the same time easy...from the groups injected once with the tumor vaccine were rechallenged with viable tumor...
- Heat shock protein suicide gene-based tumor vaccine provokes antitumor activity.
- Newspaper article from: Life Science Weekly December 7, 2004 700+ words
...shock protein suicide gene-based tumor vaccine provokes antitumor activity. According...developed an in vivo HSP-suicide gene tumor vaccine by generating a recombinant replication...use of the in vivo HSP/suicide gene tumor vaccine in therapy for human solid tumors...
- Aventis and Medigene Sign Strategic Alliance; Aventis Pharma and MediGene Sign...
- Press release article from: PR Newswire April 7, 2000 700+ words
...development agreement for MediGene's tumor vaccine to treat malignant melanoma. MediGene's tumor vaccine approach is based on the transduction...MediGene's clinical trial program of a tumor vaccine to treat malignant melanoma is expected...
- GMCSF gene modified tumor vaccine shows promise in advanced lung cancer.
- Newspaper article from: Biotech Week November 19, 2003 700+ words
...NewsRx.net) -- A GMCSF gene modified tumor vaccine has shown promise for the treatment...a GMCSF gene transduced autologous tumor vaccine (GVAX), 83 patients were entered...Release (GVAX (GMCSF gene modified tumor vaccine) in advanced stage non small cell...
- Therapy Recognizes Receptor Mutation, Prevents New Melanoma Formation.(tumor...
- Newspaper article from: Immunotherapy Weekly January 23, 2002 700+ words
...researchers say they have created a tumor vaccine that targets mutated receptors on malignant...university's medical center created the tumor vaccine using dendritic cells, which while...than 60% of the mice survived after tumor vaccine therapy, and all of the mice survived...
- Tumor vaccine therapy reviewed.
- Newspaper article from: Science Letter December 7, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Researchers review tumor vaccine therapy in a recent issue of Blood. According to published...Prod'homme published their findings in Blood (The APCs of tumor vaccine therapy. Blood, 2004;104(7):1915-1916). Additional...
