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Antigen specificity studied in autoimmune encephalomyelitis in DA rats.
2003 AUG 20 - (NewsRx.com & NewsRx.net) -- Antigen specificity and TCR repertoire, and TCR-based DNA vaccine therapy in myelin basic protein-induced autoimmune encephalomyelitis were characterized in DA rats.
According to a study from Japan, "Like Lewis rats, DA rats are an experimental autoimmune encephalomyelitis (EAE)-susceptible strain and develop severe EAE upon immunization with myelin basic protein (MBP). However, there are several differences between the two strains. In the present study we induced acute EAE in DA rats by immunization with MBP and MBP peptides and examined the antigen specificity and TCR repertoire of encephalitogenic T cells."
"It was found that although immunization with MBP and a peptide corresponding to its 62-75 sequence (MBP[subscript]62-75) induced clinical EAE, the responses of lymph node T cells isolated from MBP-immunized rats to MBP[subscript]62-75 was marginal, indicating that this peptide contains major encephalitogenic, but not immunodominant, epitopes," reported Akira Miyakoshi and colleagues at Tokyo Metropolitan Institute for Neuroscience. "The TCR analysis by CDR3 spectratyping of spinal cord T cells revealed that V-beta-10 and V-beta-15 spectratype expansion was always found in MBP[subscript]62-75-immunized symptomatic rats. On the basis of these findings, we examined the encephalitogenicity of V-beta-10- and V-beta-15-positive T cells."
The researchers found, "First, the adoptive transfer experiments revealed that ...
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Source: HighBeam Research, Antigen specificity studied in autoimmune encephalomyelitis in DA...