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Vaccination programs should seek to reduce probability of infection.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Vaccination programs that reduce the probability of infection are more likely to lead to eradication than are programs that slow growth rates in patients already affected.
According to recent research published in the journal Proceedings of the Royal Society of London Series B - Biological Sciences, "An aim of some vaccination programs is to reduce the prevalence of an infectious disease and ultimately to eradicate it. We show that eradication success depends on the type of vaccine as well as on the vaccination coverage."
"Vaccines that reduce the parasite within-host growth rate select for higher parasite virulence and this evolution may both increase the prevalence of the disease and prevent disease eradication," stated Sylvain Gandon and colleagues at the University of Edinburgh in the U.K. "By contrast, vaccines that reduce the probability of infection select against virulence and may lead more easily to eradication. In some cases, epidemiological feedback on parasite evolution yields an evolutionary bistable situation where, for intermediate vaccination coverage, parasites can evolve ...
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...the Proceedings of the Royal Society of London Series B - Biological Sciences...journal Proceedings of the Royal Society of London Series B - Biological Sciences, contact the publisher: Royal Society of London, 6 Carlton House...
Source: HighBeam Research, Vaccination programs should seek to reduce probability of infection.