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Vaccines to treat human papillomavirus-associated disease under development.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Therapeutic vaccines to treat human papillomavirus-associated disease are currently under development.
"There is a high prevalence of diseases caused by human papillomavirus (HPV) infection. Unfortunately, current treatments are inadequate. However, because there is evidence to support a role for the immune system in host defense against this virus, an immunotherapeutic approach is warranted," a researcher in Canada reports.
"The existing immunotherapies are not completely effective, nor are they durable," said N. Randall Chu at Stressgen Biotechnologies Corporation. "In addition, natural history studies associated with spontaneous regression have provided little guidance to the design of successful interventions. This state of knowledge has encouraged efforts towards the development of novel immunotherapeutic strategies. Successful preclinical studies of therapeutic vaccine candidates have led to clinical studies for a variety of HPV-associated indications, such as anogenital warts and cervical and anal intraepithelial neoplasia."
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- Is human papillomavirus an infectious cause of non-cervical anogenital tract...
- Magazine article from: British Medical Journal Strickler, Howard D. Schiffman, Mark H. September 13, 1997 700+ words
...demonstrate in the study of human papillomavirus infection as a cause of...In cervical cancers human papillomavirus DNA can be detected in...Moreover, cervical human papillomavirus has been detected before...
- Cigarette smoking and human papillomavirus in patients with reported cervical...
- Magazine article from: British Medical Journal Burger, M.P.M. Hollema, H. Gouw, A.S.H. Pieters, W.J.L.M. Quint, W.G.V. March 20, 1993 700+ words
...smoking and infection with oncogenic human papillomavirus. It has been suggested that smoking...the infection and persistence of human papillomavirus. Design--Cross sectional epidemiological...analysis of cervical scrapes for human papillomavirus, and morphological examination...
- Predictive value of human papillomavirus type for histological diagnosis of...
- Magazine article from: British Medical Journal Burger, M.P.M. Hollema, H. Pieters, W.J.L.M. Quint, W.G.V. January 14, 1995 700+ words
...The broad spectrum of different human papillomavirus types has recently been grouped...tree lead to specific groups of human papillomavirus types with similar tissue tropism...viruses such as types 31 and 33. Human papillomavirus type 18 belongs to a separate main...
- Human papillomavirus infection: pathogenesis suggests new strategies for...
- Magazine article from: British Medical Journal Hines, Jeffrey F. Ghim, Shin-Je Jenson, A. Bennett March 2, 1996 700+ words
...existing scientific evidence of human papillomavirus and its association with invasive...To date, more than 70 types of human papillomavirus have been described. Each type...between anogenital infection with human papillomavirus and the development of cervical...
- Anal human papillomavirus infection in heterosexuals with genital warts:...
- Magazine article from: British Medical Journal Sonnex, C. Scholefield, J.H. Kocjan, G. Kelly, G. Whatrup, C. Mindel, A. Northover, J.M.A. November 16, 1991 700+ words
...subclinical manifestations of anal human papillomavirus infection have been well reported...the prevalence of subclinical anal human papillomavirus infection in heterosexual people...previously. The mode of transmission of human papillomavirus to the anus is poorly understood...
- Human papillomavirus testing and the management of women with mildly abnormal...
- Magazine article from: British Medical Journal Rebello, Gemma Hallam, Nick Smart, George Farquharson, David McCafferty, Jane April 14, 2001 700+ words
...pilot scheme screening women for human papillomavirus if they have a mildly dyskaryotic...1] How reliable is testing for human papillomavirus as a marker for high grade disease...consented to the study were tested for human papillomavirus (high risk types only) with the...
- Cross sectional study of conventional cervical smear, monolayer cytology, and...
- Magazine article from: British Medical Journal Coste, Joel Cochand-Priollet, Beatrix de Cremoux, Patricia Le Gales, Catherine Cartier, Isabelle Molinie, Vincent Labbe, Sylvain Vacher-Lavenu, Marie-Cecile Vielh, Philippe April 5, 2003 700+ words
...tests, monolayer cytology, and human papillomavirus testing for screening for cervical...high incidence of abnormalities. Human papillomavirus testing associated with monolayer...cytology, possibly combined with human papillomavirus testing, is replacing conventional...
- Serologically diagnosed infection with human papillomavirus type 16 and risk...
- Magazine article from: British Medical Journal Lehtinen, Matti Dillner, Joakim Knekt, Paul Luostarinen, Tapio Aromaa, Arpo Kirnbauer, Reinhard Koskela, Pentti Paavonen, Jorma Peto, Richard Schiller, John T. Hakama, Matti March 2, 1996 700+ words
...Objective--To study human papillomavirus type 16 in the aetiology...of past infection with human papillomavirus type 16. Subjects...of IgG antibodies to human papillomavirus type 16. Results...
- Prospective seroepidemiological study of role of human papillomavirus in...
- Magazine article from: British Medical Journal Bjorge, Tone Dillner, Joakim Anttila, Tarja Engeland, Anders Hakulinen, Timo Jellum, Egil Lehtinen, Matti Luostarinen, Tapio Paavonen, Jorma Pukkala, Eero Sapp, Martin Schiller, John Youngman, Linda Thoresen, Steinar September 13, 1997 700+ words
...epidemiological data have implicated human papillomavirus as a cause of cervical cancer.[1 2] Human papillomavirus DNA has been detected in more than 90% of invasive cancers.[3] Human papillomavirus type 16 is the dominant subtype...
- Prospective seroepidemiological evidence that human papillomavirus type 16...
- Magazine article from: British Medical Journal Dillner, J. Knekt, P. Schiller, J.T. Hakulinen, T. November 18, 1995 700+ words
...of the major type of human papillomavirus that is associated with...is not clear whether human papillomavirus infection is a measurable...cancer. Whereas cervical human papillomavirus infection is a sexually...
Source: HighBeam Research, Vaccines to treat human papillomavirus-associated disease under...