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Role of dendritic cells in chronic lymphocytic leukemia reviewed.

Vaccine Weekly

| August 13, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 AUG 13 - (NewsRx.com & NewsRx.net) -- The role of monocyte-derived dendritic cells in chronic lymphocytic leukemia has been reviewed in the journal Leukemia and Lymphoma.

According to published research from France, "Chronic lymphocytic leukemia (CLL) results from the accumulation of small mature, slowly dividing, monoclonal B lymphocytes. The clinical course of this disease is heterogeneous, with some patients progressing rapidly with early death whilst others exhibit a more stable, possibly, non-progressing disease lasting many years. Despite progress in therapy, relapse invariably occurs and the disease remains incurable."

"The clinical management of CLL is therefore challenging and considerable effort has been directed towards novel therapeutic strategies aimed at reducing the disease relapse rate," said Francoise Vuillier and Guillaume Dighiero at the Institut Pasteur in Paris. "Recent insights into the role of dendritic cells as the pivotal antigen-presenting cells that initiate immune responses may provide the basis for generating more effective antitumor immune responses. Consequently, dendritic cells constitute an attractive approach in the context of CLL."

"However, understanding the ...

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