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RNA transfection of dendritic cells induces immunity against breast cancer.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Transfection of dendritic cells with RNA induced CD4- and CD8-mediated T cell immunity against breast cancer and revealed the immunodominance of presented T cell epitopes.
"Transfection of dendritic cells (DC) with tumor-derived RNA has recently been shown to elicit tumor-specific CTL capable of recognizing and lysing a variety of tumor cells. In our study we analyzed the induction of HLA class I- and II-restricted T cell responses against MCF-7 breast cancer cells. Using this approach we were able to elicit CD4- and CD8-mediated antitumor responses," researchers in Germany report.
"The CTL specifically lysed MCF-7 cells and DC electroporated with MCF-7 RNA, but spared control cell lines," said Martin R. Muller and colleagues at the University of Tubingen. "The specificity of the cytotoxic activity was confirmed in cold target inhibition assays and using monoclonal antibodies blocking HLA class I molecules. Interestingly, these polyclonal cytotoxic T cells recognized selectively two epitopes derived from the MUC1 and Her-2/neu tumor antigens. The induced Th cells ...
- Dendritic cells pulsed with HIV TAT fusion protein induce antigen-specific CTLs.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...NewsRx.net) -- Dendritic cells (DCs) pulsed with...of Ags into human dendritic cells (DC)," according...neu+ ovarian and breast cancer cell lines. The...monocyte-derived dendritic cells. J Immunol, 2003...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- Dendritic cells heterogeneity and its role in cancer immunity.(Review Article)
- Magazine article from: Journal of Cancer Research and Therapeutics Kah-Wai, Lin Jacek, Tabarkiewicz Jacek, Rolinski April 1, 2006 700+ words
...Tabarkiewicz. Jacek, Rolinski. Jacek Dendritic cells are the most potent 'professional...primary immune response initiation. Dendritic cells originate from bone marrow progenitors...subsequently give rise to immature dendritic cells, which reside in peripheral tissues...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Future psoriasis drugs may target role of dendritic cells.(Rx)
- Magazine article from: Internal Medicine News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...been published since 2003) suggest dendritic cells also play a role by activating the...
- Decidual CD83+ dendritic cells implicated in some recurrent miscarriages.
- Magazine article from: Women's Health Weekly April 15, 2004 700+ words
...NewsRx.net) -- Decidual CD83+ dendritic cells may contribute to some cases of recurrent...Potent immunostimulatory (CD83) dendritic cells have recently been identified in the...sought to determine "whether decidual dendritic cells could play a role in the etiology...
